Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 5/20 | 0.36 |
| ▸ | HINT1 | P49773 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | MGMT | P16455 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19863222 | 0.87 | ADORA2A (0.40) | NT5EHINT1ADORA2AADORA3ADORA2B | |
| SCHEMBL16368444 | 0.87 | ADORA2A (0.40) | NT5EHINT1ADORA2AADORA3ADORA2B | |
| SCHEMBL20058892 | 0.87 | ADORA3 (0.40) | NT5EHINT1ADORA2ASLC29A1ADORA3 | |
| SCHEMBL17378466 | 0.84 | HINT1 (0.45) | NT5EHINT1ADORA3 | |
| SCHEMBL25713475 | 0.81 | HINT1 (0.43) | NT5EHINT1ADORA2ASLC29A1ADORA3 | |
| SCHEMBL16481020 | 0.80 | ADORA2A (0.53) | ADORA2ASLC29A1ADORA3ADORA2BADORA1 | |
| SCHEMBL25723814 | 0.80 | HINT1 (0.42) | NT5EHINT1ADORA2ASLC29A1ADORA3 | |
| SCHEMBL18877202 | 0.80 | ADORA2A (0.33) | NT5EHINT1ADORA2ASLC29A1ADORA3 | |
| SCHEMBL16480806 | 0.80 | ADORA2A (0.34) | NT5EHINT1ADORA2ASLC29A1ADORA3 | |
| SCHEMBL25721826 | 0.79 | ALDH1A1 (0.41) | NT5EHINT1ADORA2ASLC29A1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170143751-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen Pharmaceuticals, Inc. | 2017-05-25 | — | — | US | disclosed |
| US-9603863-B2 | Substituted nucleosides, nucleotides and analogs thereof | ALIOS BIOPHARMA, INC. (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150366887-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen Pharmaceuticals, Inc. | 2015-12-24 | — | — | US | disclosed |
| US-20150011497-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen Pharmaceuticals, Inc. | 2015-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170143751-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | PNP, NUDT1, NT5C3B | NT5E 9/4885HINT1 137/4885ADORA2A 71/4885 |
| US-20150366887-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | PNP, NUDT1, NT5C3B | NT5E 9/4885HINT1 137/4885ADORA2A 71/4885 |
| US-20150011497-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | PNP, NUDT1, NT5C3B | NT5E 6/4885HINT1 77/4885ADORA2A 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.