SCHEMBL1738189

SCHEMBL1738189

Cc1c(C)n(Cc2cccc(F)c2)c2c(-c3ccc(Cl)cc3)nccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
HPGD P15428 2/20 0.40
KDM4E B2RXH2 2/20 0.40
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C19 P33261 2/20 0.40
CYP2C9 P11712 1/20 0.40
PKM P14618 1/20 0.40
CLPP Q16740 1/20 0.39
MAPT P10636 5/20 0.39
FABP4 P15090 1/20 0.39
IDO1 P14902 1/20 0.39
CYP2D6 P10635 1/20 0.38
ATM Q13315 1/20 0.38
HTR6 P50406 1/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
GRIN1 Q05586 1/20 0.37
GRIN2B Q13224 1/20 0.37
MCL1 Q07820 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1737359 0.99 ALDH1A1 (0.39) ALDH1A1HPGDKDM4ECYP1A2CYP3A4
SCHEMBL1735606 0.92 MAPT (0.43) ALDH1A1HPGDKDM4ECYP1A2CYP3A4
SCHEMBL1738536 0.91 GRIN1 (0.41) ALDH1A1KDM4ECYP1A2CYP3A4CYP2C19
Hydrochloric Acid SCHEMBL1738352 0.91 MAPT (0.43) ALDH1A1HPGDKDM4ECYP1A2CYP3A4
Hydrochloric Acid SCHEMBL1736852 0.90 GRIN1 (0.40) KDM4ECYP1A2CYP3A4CYP2C19MAPT
SCHEMBL1735469 0.90 POLB (0.44) ALDH1A1HPGDKDM4EMAPTFABP4
SCHEMBL1738241 0.90 FABP4 (0.44) ALDH1A1KDM4ECYP1A2CYP3A4CYP2C19
SCHEMBL1737172 0.89 MAPT (0.44) ALDH1A1HPGDKDM4ECYP1A2CYP3A4
Hydrochloric Acid SCHEMBL1738998 0.89 POLB (0.44) ALDH1A1HPGDKDM4EMAPTFABP4
Hydrochloric Acid SCHEMBL1736922 0.89 FABP4 (0.43) ALDH1A1KDM4ECYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed