Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | MB | P02144 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396612 | 0.71 | MKNK2 (0.35) | MB | |
| SCHEMBL661744 | 0.71 | KDR (0.42) | TYRO3DYRK1BJUNNFKB1NFKB2 | |
| SCHEMBL31267899 | 0.71 | TYRO3 (0.37) | TYRO3DYRK1BMBJUNNFKB1 | |
| SCHEMBL2600058 | 0.71 | NNMT (0.38) | TYRO3DYRK1BKDM4E | |
| SCHEMBL18168295 | 0.70 | IDH1 (0.42) | TYRO3DYRK1BJUNNFKB1NFKB2 | |
| SCHEMBL17396441 | 0.69 | NOS1 (0.35) | KDM4E | |
| SCHEMBL30935211 | 0.68 | NNMT (0.41) | TYRO3DYRK1BKDM4E | |
| SCHEMBL30555417 | 0.68 | KDM4E (0.32) | TYRO3DYRK1BKDM4E | |
| SCHEMBL26627797 | 0.68 | TYRO3 (0.34) | TYRO3DYRK1BJUNNFKB1NFKB2 | |
| SCHEMBL17396406 | 0.66 | HDAC8 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | disclosed |