Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 13/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 13/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397271 | 0.85 | TAAR1 (0.42) | — | |
| SCHEMBL17397174 | 0.82 | PIK3CD (0.42) | — | |
| SCHEMBL17397202 | 0.80 | PIK3CA (0.40) | — | |
| SCHEMBL17397285 | 0.80 | PIK3CD (0.44) | PIM1PIM2XDHMAPTDHFR | |
| SCHEMBL17397176 | 0.79 | PIK3CD (0.41) | — | |
| SCHEMBL17397122 | 0.78 | TAAR1 (0.37) | — | |
| SCHEMBL17397123 | 0.78 | PIK3CD (0.45) | — | |
| SCHEMBL17397192 | 0.77 | PIK3CD (0.37) | XDHMAPTRIPK3 | |
| SCHEMBL17397294 | 0.74 | PIK3CD (0.46) | — | |
| SCHEMBL17397173 | 0.71 | PIK3CD (0.41) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |