Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397174 | 0.87 | PIK3CD (0.42) | PIK3CDPIK3CBPIK3CASLC11A2PIK3CG | |
| SCHEMBL18988992 | 0.84 | PIK3CD (0.42) | PIK3CDPIK3CBPIK3CASLC11A2MAPT | |
| SCHEMBL19006238 | 0.84 | PIK3CD (0.43) | PIK3CDPIK3CBPIK3CASLC11A2ALKBH3 | |
| SCHEMBL18989286 | 0.83 | PIK3CD (0.40) | PIK3CDPIK3CBPIK3CAPIK3CG | |
| SCHEMBL17397202 | 0.79 | PIK3CA (0.40) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17397271 | 0.78 | TAAR1 (0.42) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17397146 | 0.77 | PIK3CD (0.40) | PIK3CDPIK3CBPIK3CASLC11A2PIK3CG | |
| SCHEMBL17397148 | 0.77 | PIK3CD (0.40) | PIK3CDPIK3CBPIK3CASLC11A2PIK3CG | |
| SCHEMBL17397122 | 0.76 | TAAR1 (0.37) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL19006295 | 0.76 | PIK3CD (0.41) | PIK3CDPIK3CBPIK3CASLC11A2ALKBH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |