Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398012 | 0.82 | ALDH1A1 (0.48) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL17397926 | 0.81 | KDR (0.49) | KDRHTTALDH1A1HPGDCDK7 | |
| SCHEMBL17398079 | 0.80 | KMT2A (0.39) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL17397982 | 0.79 | ALDH1A1 (0.43) | KDRKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL17397920 | 0.78 | ALDH1A1 (0.50) | ITKKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL17397956 | 0.77 | ITK (0.64) | ITKGSK3AGSK3BKDRKMT2A | |
| SCHEMBL17398031 | 0.75 | KDM4E (0.44) | KMT2ANPC1RAB9AMEN1POLB | |
| SCHEMBL17397918 | 0.74 | ALDH1A1 (0.47) | KMT2ANPC1RAB9AMEN1POLB | |
| SCHEMBL17398026 | 0.73 | ITK (0.48) | ITKKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL17398060 | 0.73 | AURKA (0.46) | GSK3AGSK3BKDRCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |