Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | CD44 | P16070 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycolic Acid SCHEMBL174591 | 0.92 | HTR2A (0.41) | HTR2AHTR2CHDAC9DRD2SLC6A2 | |
| Succinic Acid SCHEMBL175159 | 0.92 | HTR2A (0.41) | HTR2AHTR2CALDH1A1DRD2SLC6A2 | |
| Adipic Acid SCHEMBL173981 | 0.89 | L3MBTL1 (0.41) | HTR2AHTR2CHDAC9ALDH1A1DRD2 | |
| SCHEMBL173319 | 0.87 | HTR2A (0.51) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| Alpha-Ketoglutaric Acid SCHEMBL174485 | 0.86 | HTR2A (0.37) | HTR2AHTR2CALDH1A1DRD2SLC6A2 | |
| SCHEMBL174465 | 0.86 | HTR2C (0.43) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5317898 | 0.85 | HTR2A (0.50) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| Citric Acid SCHEMBL173747 | 0.85 | SLC13A5 (0.39) | HTR2AHTR2CALDH1A1LMNABLM | |
| Phosphoric Acid SCHEMBL174685 | 0.84 | HTR2A (0.44) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| Malonic Acid SCHEMBL12504943 | 0.77 | HTR2C (0.64) | HTR2CDRD2PNMTCD44MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |