Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL175159 | 0.94 | HTR2A (0.41) | HTR2AHTR2CL3MBTL1DRD2SLC6A2 | |
| Adipic Acid SCHEMBL173981 | 0.89 | L3MBTL1 (0.41) | HTR2AHTR2CL3MBTL1MAPK1DRD2 | |
| Malonic Acid SCHEMBL174326 | 0.86 | HTR2A (0.41) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| Glycolic Acid SCHEMBL174591 | 0.86 | HTR2A (0.41) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| SCHEMBL173319 | 0.81 | HTR2A (0.51) | HTR2AHTR2CMAPK1DRD2SLC6A2 | |
| Alpha-Ketoglutaric Acid SCHEMBL16464850 | 0.80 | HTR2C (0.53) | HTR2CL3MBTL1MAPK1SLC13A3EGLN1 | |
| Hydrochloric Acid SCHEMBL5317898 | 0.80 | HTR2A (0.50) | HTR2AHTR2CDRD2SLC6A2SLC6A4 | |
| Citric Acid SCHEMBL173747 | 0.80 | SLC13A5 (0.39) | HTR2AHTR2CL3MBTL1MAPK1ALDH1A1 | |
| Phosphoric Acid SCHEMBL174685 | 0.79 | HTR2A (0.44) | HTR2AHTR2CL3MBTL1DRD2SLC6A2 | |
| SCHEMBL174465 | 0.78 | HTR2C (0.43) | HTR2AHTR2CDRD2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |