Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.37 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.33 |
| ▸ | SLC13A5 | Q86YT5 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycolic Acid SCHEMBL174591 | 0.87 | HTR2A (0.41) | LMNAHTR2AHTR2CBLM | |
| Malonic Acid SCHEMBL174326 | 0.85 | HTR2A (0.41) | LMNAHTR2AHTR2CALDH1A1BLM | |
| Succinic Acid SCHEMBL175159 | 0.85 | HTR2A (0.41) | KDM4ELMNACYP1A2MEN1KMT2A | |
| SCHEMBL175226 | 0.83 | SLC13A5 (0.36) | SLC13A5KDM4ELMNACYP1A2CYP2D6 | |
| Adipic Acid SCHEMBL173981 | 0.83 | L3MBTL1 (0.41) | CYP1A2HTR2AHTR2CALDH1A1MAPK1 | |
| SCHEMBL173319 | 0.80 | HTR2A (0.51) | CYP2D6MEN1KMT2AHTR2AHTR2C | |
| Alpha-Ketoglutaric Acid SCHEMBL174485 | 0.80 | HTR2A (0.37) | CYP1A2HTR2AHTR2CALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL5317898 | 0.79 | HTR2A (0.50) | CYP2D6MEN1KMT2AHTR2AHTR2C | |
| Phosphoric Acid SCHEMBL174685 | 0.78 | HTR2A (0.44) | HTR2AHTR2CL3MBTL1 | |
| Citric Acid SCHEMBL27499903 | 0.77 | PNMT (0.56) | SLC13A5KDM4ELMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |