Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLG | P54098 | 2/20 | 0.64 |
| ▸ | P2RY2 | P41231 | 13/20 | 0.41 |
| ▸ | P2RY4 | P51582 | 8/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | P2RY6 | Q15077 | 7/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.38 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856521 | 0.88 | POLG (0.50) | POLGP2RY2P2RY4P2RY6P2RX1 | |
| SCHEMBL9856523 | 0.82 | POLG (0.63) | POLGP2RY2P2RY4P2RY6 | |
| SCHEMBL599700 | 0.80 | POLG (0.66) | POLGP2RY2P2RY4ALBP2RY6 | |
| SCHEMBL599699 | 0.80 | POLG (0.66) | POLGP2RY2P2RY4ALBP2RY6 | |
| SCHEMBL18852597 | 0.80 | POLG (0.63) | POLGP2RY2P2RY4P2RY6P2RX1 | |
| SCHEMBL16805404 | 0.80 | POLG (0.63) | POLGP2RY2P2RY4P2RY6P2RX1 | |
| SCHEMBL18858934 | 0.80 | POLG (0.63) | POLGP2RY2P2RY4P2RY6P2RX1 | |
| SCHEMBL13199313 | 0.80 | POLG (0.71) | POLGP2RY2P2RY4ALBP2RY6 | |
| SCHEMBL18870814 | 0.80 | POLG (0.63) | POLGP2RY2P2RY4P2RY6P2RX1 | |
| SCHEMBL6909903 | 0.80 | POLG (0.71) | POLGP2RY2P2RY4ALBP2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9861652-B2 | 2′ Fluoronucleosides | EMORY UNIVERSITY (US) | 2018-01-09 | — | — | US | disclosed |
| US-20160158266-A1 | 2' FLUORONUCLEOSIDES | EMORY UNIVERSITY | 2016-06-09 | — | — | US | disclosed |
| US-9180138-B2 | 2′-fluoronucleosides | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| US-20130157971-A1 | 2'-FLUORONUCLEOSIDES | SCHINAZI RAYMOND F (US) | 2013-06-20 | — | — | US | disclosed |
| US-8168583-B2 | 2-fluoronucleosides | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| EP-2392580-A1 | 2'-fluoronucleosides | Emory University (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2390257-A1 | 2'-fluoronucleosides | Emory University (US) | 2011-11-30 | — | — | EP | disclosed |
| US-20110256952-A1 | GOLF CLUB, SHAFT REPLACING METHOD AND HEAD REPLACING METHOD | BRIDGESTONE SPORTS CO., LTD. (JP) | 2011-10-20 | — | — | US | disclosed |
| US-20100173863-A1 | 2-Fluoronucleosides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-07-08 | — | — | US | disclosed |
| US-7662938-B2 | 2′-fluoronucleosides | EMORY UNIVERSITY (US) | 2010-02-16 | — | — | US | disclosed |
| US-20080300398-A1 | 2'-FLUORONUCLEOSIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-04 | — | — | US | disclosed |
| US-7307065-B2 | 2′-Fluoronucleosides | EMORY UNIVERSITY (US) | 2007-12-11 | — | — | US | disclosed |
| EP-1754710-A2 | 2'-Fluoroncucleosides | Emory University (US) | 2007-02-21 | — | — | EP | disclosed |
| US-6911424-B2 | 2′-fluoronucleosides | EMORY UNIVERSITY (US) | 2005-06-28 | — | — | US | disclosed |
| US-20040254141-A1 | 2'-Fluoronucleosides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-12-16 | — | — | US | disclosed |
| US-20020198171-A1 | 2'-fluoronucleosides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-12-26 | — | — | US | disclosed |
| US-6348587-B1 | PURINE OR PYRIMIDINE BASE DERIVATIVES; ANTICANCER, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS; TREATING HIV AND HEPATITIS | EMORY UNIVERSITY | 2002-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198171-A1 | 2'-fluoronucleosides | NSUN2, PNP, FDPS | POLG 2013/4885P2RY2 1102/4885P2RY4 1421/4885 |
| US-20040254141-A1 | 2'-Fluoronucleosides | NSUN2, PNP, FDPS | POLG 2013/4885P2RY2 1102/4885P2RY4 1421/4885 |
| US-20100173863-A1 | 2-Fluoronucleosides | PNP, BCL3, NPC1 | POLG 1938/4885P2RY2 1197/4885P2RY4 1631/4885 |
| US-20080300398-A1 | 2'-FLUORONUCLEOSIDES | METTL3, BCL3, PNP | POLG 3270/4885P2RY2 705/4885P2RY4 733/4885 |
| US-20160158266-A1 | 2' FLUORONUCLEOSIDES | PNP, BCL3, NPC1 | POLG 2001/4885P2RY2 1271/4885P2RY4 1615/4885 |
| US-20130157971-A1 | 2'-FLUORONUCLEOSIDES | PNP, BCL3, FUBP3 | POLG 1914/4885P2RY2 1271/4885P2RY4 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.