SCHEMBL1741372

SCHEMBL1741372

CC(C(=O)O)c1cc(I)c(O)c(I)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 11/20 0.44
TTR P02766 1/20 0.42
PTGS1 P23219 10/20 0.42
CXCR1 P25024 4/20 0.42
CXCR2 P25025 4/20 0.42
LMNA P02545 3/20 0.42
SLC22A6 Q4U2R8 3/20 0.42
MAPT P10636 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
PMP22 Q01453 2/20 0.42
CXCL8 P10145 2/20 0.42
RECQL P46063 1/20 0.42
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
CYP3A4 P08684 1/20 0.42
HPGD P15428 1/20 0.42
MAPK1 P28482 1/20 0.42
HSD17B10 Q99714 1/20 0.42
THPO P40225 1/20 0.42
HIF1A Q16665 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1525945 0.85 THRB (0.58) PTGS2TTRPTGS1LMNAMAPT
SCHEMBL5488854 0.80 AKR1C3 (0.47) PTGS2PTGS1SLC22A6CYP3A4AKR1C3
SCHEMBL490872 0.80 AKR1B1 (0.47) PTGS2PTGS1CXCR1CXCR2LMNA
SCHEMBL9221016 0.78 AKR1C3 (0.46) PTGS2PTGS1CXCR1CXCR2LMNA
SCHEMBL291001 0.77 PTGS2 (0.47) PTGS2PTGS1CXCR1CXCR2LMNA
SCHEMBL15506106 0.77 PTGS2 (0.47) PTGS2PTGS1CXCR1CXCR2LMNA
SCHEMBL15506197 0.77 PTGS2 (0.47) PTGS2PTGS1CXCR1CXCR2LMNA
SCHEMBL5964865 0.77 TTR (0.48) PTGS2TTRPTGS1CXCR1CXCR2
SCHEMBL5850729 0.77 CA1 (0.52) PTGS2LMNAALDH1A1
SCHEMBL298241 0.77 AKR1C3 (0.53) PTGS2PTGS1LMNASLC22A6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009147400-A1 STEM CELL CULTURE MEDIA AND METHODS ITI SCOTLAND LIMITED (GB) 2009-12-10 WO claimed
EP-1432310-A4 METHOD TO TREAT CHRONIC HEART FAILURE AND/OR ELEVATED CHOLESTEROL LEVELS USING 3,5-DIIODOTHYROPROPIONIC ACID AND METHOD TO PREPARE SAME UNIV ARIZONA (US) 2006-06-21 EP claimed
US-20040234592-A1 Mixture containing thyroid hormone , ethanolamine and emulsifier KARO BIO AB (SE) 2004-11-25 US claimed
EP-1432310-A2 METHOD TO TREAT CHRONIC HEART FAILURE AND/OR ELEVATED CHOLESTEROL LEVELS USING 3,5-DIIODOTHYROPROPIONIC ACID AND METHOD TO PREPARE SAME The Arizona Board of Regents on Behalf of the University of Arizona (US) 2004-06-30 EP claimed
EP-1404413-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2004-04-07 EP claimed
EP-1398024-A2 Uses for thyroid hormone compounds KARO BIO AB (SE) 2004-03-17 EP claimed
EP-0831769-B1 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KAROBIO AB (SE) 2003-10-15 EP claimed
EP-1328265-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2003-07-23 EP claimed
WO-2002089917-A2 DERMATOLOGICAL FORMULATIONS KARO BIO AB (SE) 2002-11-14 WO claimed
US-20020123521-A1 Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds KOO, CATHERINE, DR 2002-09-05 US claimed
WO-2002060389-A2 METHOD TO TREAT CHRONIC HEART FAILURE AND/OR ELEVATED CHOLESTEROL LEVELS USING 3,5-DIIODOTHYROPROPIONIC ACID AND METHOD TO PREPARE SAME THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2002-08-08 WO claimed
US-6380255-B1 TOPICALLY APPLYING TO SKIN THYROID HORMONE COMPOUND TOGETHER WITH A BASE FOR THERAPY OF SKIN ATROPHY KARO BIO AB (SE) 2002-04-30 US claimed
WO-2002005834-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS KARO BIO AB (SE) 2002-01-24 WO claimed
US-6221911-B1 REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT KARO BIO AB (SE) 2001-04-24 US claimed
EP-0831769-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1998-04-01 EP claimed
WO-1996040048-A9 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS 1997-03-27 WO claimed
WO-1996040048-A2 NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS KARO BIO AB (SE) 1996-12-19 WO claimed
US-11479802-B2 Assays for screening activity of modulators of members of the hydroxy steroid (17-beta) dehydrogenase (HSD17B) family REGENERON PHARMACEUTICALS, INC. (US) 2022-10-25 US disclosed
WO-1995022992-A1 METHOD AND COMPOSITIONS FOR INCREASING THE SERUM HALF-LIFE OF PHARMACOLOGICALLY ACTIVE AGENTS CHIRON CORPORATION (US) 1995-08-31 WO disclosed
US-5273885-A Using a polyiodothyronine analog of a phenyl compound containing a hydroxyl group ortho to an iodine SYNTEX (U.S.A.) INC. (US) 1993-12-28 US disclosed