Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 11/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 11/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.47 |
| ▸ | CDC42 | P60953 | 1/20 | 0.47 |
| ▸ | RAC1 | P63000 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | FABP2 | P12104 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490579 | 0.82 | TDP1 (0.55) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL32660739 | 0.82 | TDP1 (0.55) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL28183228 | 0.81 | TDP1 (0.53) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL1741372 | 0.80 | PTGS2 (0.44) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL3227547 | 0.80 | THRB (0.60) | TSHRCYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL11218780 | 0.79 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL30526268 | 0.79 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL23513402 | 0.79 | CYP2C9 (0.47) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| SCHEMBL788149 | 0.78 | ALDH1A1 (0.57) | PTGS1TSHRCYP1A2FOLH1CYP3A4 | |
| SCHEMBL11112214 | 0.78 | ESR1 (0.46) | PTGS1TSHRFOLH1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113402490-B | Preparation method of 1,2,6, 7-tetrahydro-8H-indeno [5,4-b ] furan-8-one | 白银京宇新药业有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-113402490-A | Preparation method of 1,2,6, 7-tetrahydro-8H-indeno [5,4-b ] furan-8-one | 白银京宇新药业有限公司 | 2021-09-17 | — | — | CN | disclosed |
| EP-1783221-A1 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | MIGENIX Corp. (US) | 2007-05-09 | — | — | EP | disclosed |
| US-7001729-B2 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | MIGENIX CORP. (US) | 2006-02-21 | — | — | US | disclosed |
| US-6906175-B2 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor. | MIGENIX CORP. (US) | 2005-06-14 | — | — | US | disclosed |
| US-6902908-B2 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | MIGENIX CORP. (US) | 2005-06-07 | — | — | US | disclosed |
| US-6887670-B2 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | MIGENIX CORP. (US) | 2005-05-03 | — | — | US | disclosed |
| US-20050064530-A1 | PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR | MIGENIX CORP. | 2005-03-24 | — | — | US | disclosed |
| US-20050019835-A1 | PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR | MIGENIX CORP. | 2005-01-27 | — | — | US | disclosed |
| US-20050003353-A1 | PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR | MIGENIX CORP. | 2005-01-06 | — | — | US | disclosed |
| US-20050003352-A1 | PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR | MIGENIX CORP. | 2005-01-06 | — | — | US | disclosed |
| US-20040241801-A1 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | MITOKOR, INC. | 2004-12-02 | — | — | US | disclosed |
| EP-1283884-A2 | PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR | MITOKOR (US) | 2003-02-19 | — | — | EP | disclosed |
| US-20020012992-A1 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | MIGENIX CORP. | 2002-01-31 | — | — | US | disclosed |
| US-20010044144-A1 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | MIGENIX CORP. | 2001-11-22 | — | — | US | disclosed |
| WO-2001085944-A2 | PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR | MITOKOR (US) | 2001-11-15 | — | — | WO | disclosed |
| WO-2000026370-A9 | ADENINE NUCLEOTIDE TRANSLOCATOR (ANT) FUSION PROTEINS AND USES THEREOF | MITOKOR (US) | 2001-11-15 | — | — | WO | disclosed |
| EP-1049780-A1 | ADENINE NUCLEOTIDE TRANSLOCATOR (ANT) FUSION PROTEINS AND USES THEREOF | MITOKOR (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-2000026370-A2 | ADENINE NUCLEOTIDE TRANSLOCATOR (ANT) FUSION PROTEINS AND USES THEREOF | MITOKOR (US) | 2000-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044144-A1 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | GART, TMEM165, SLC43A3 | AKR1C3 1316/4885AKR1C2 894/4885PTGS2 2680/4885 |
| US-20050003353-A1 | PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR | GART, TMEM165, SLC43A3 | AKR1C3 1316/4885AKR1C2 894/4885PTGS2 2680/4885 |
| US-20040241801-A1 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | GART, TMEM165, SLC43A3 | AKR1C3 1316/4885AKR1C2 894/4885PTGS2 2680/4885 |
| US-20050003352-A1 | PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR | GART, TMEM165, SLC43A3 | AKR1C3 1316/4885AKR1C2 894/4885PTGS2 2680/4885 |
| US-20050064530-A1 | PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR | GART, TMEM165, SLC43A3 | AKR1C3 1316/4885AKR1C2 894/4885PTGS2 2680/4885 |
| US-20020012992-A1 | Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor | GART, TMEM165, SLC43A3 | AKR1C3 1316/4885AKR1C2 894/4885PTGS2 2680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.