Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17399991 | 0.93 | BRD4 (0.38) | BRD4EPHX2ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL17385741 | 0.90 | ALDH1A1 (0.39) | BRD4EPHX2ALDH1A1FFAR1ESR1 | |
| SCHEMBL17385742 | 0.84 | FFAR1 (0.39) | BRD4EPHX2ALDH1A1FFAR1ESR1 | |
| SCHEMBL17400124 | 0.83 | CYP2C8 (0.40) | BRD4FFAR1 | |
| SCHEMBL17386181 | 0.82 | BRD4 (0.44) | BRD4ATMSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL17400012 | 0.79 | ATM (0.38) | BRD4ATMSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL17386007 | 0.78 | FFAR1 (0.39) | EPHX2SMN1; SMN2ALDH1A1MAPK14FFAR1 | |
| SCHEMBL17386195 | 0.78 | ALDH1A1 (0.40) | EPHX2ATMSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL205031 | 0.77 | FFAR1 (0.45) | EPHX2ALDH1A1FFAR1DRD4ADRA1D | |
| SCHEMBL17429653 | 0.77 | TDP1 (0.41) | BRD4ATMSMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643946-B2 | Tricyclic compound and use thereof | SK CHEMICALS CO., LTD. (KR) | 2017-05-09 | — | — | US | disclosed |
| US-20160009677-A1 | TRICYCLIC COMPOUND AND USE THEREOF | SK CHEMICALS CO., LTD. (KR) | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009677-A1 | TRICYCLIC COMPOUND AND USE THEREOF | GPR65, GPR119, GPR35 | BRD4 1490/4885EPHX2 2306/4885ATM 4477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.