SCHEMBL21914834

SCHEMBL21914834

N#Cc1ccc(Nc2nc(Nc3ccc(C#N)cc3)nc(Nc3ccc(C#N)cc3)n2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSK P43235 2/20 0.58
CTSS P25774 1/20 0.58
SYK P43405 1/20 0.57
CTSL P07711 1/20 0.53
CTSB P07858 1/20 0.53
KCNH2 Q12809 2/20 0.51
SCN5A Q14524 1/20 0.51
SCN9A Q15858 1/20 0.51
ABCG2 Q9UNQ0 5/20 0.50
ABCB1 P08183 3/20 0.50
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
CDC7 O00311 1/20 0.47
EGFR P00533 1/20 0.47
KDR P35968 1/20 0.47
TERT O14746 1/20 0.47
ADORA1 P30542 2/20 0.47
MERTK Q12866 1/20 0.47
ABCC3 O15438 1/20 0.47
ESR1 P03372 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21915358 0.94 CTSK (0.54) CTSKCTSSSYKCTSLCTSB
SCHEMBL24490436 0.92 ABCG2 (0.59) CTSKCTSSSYKABCG2ABCB1
SCHEMBL24490452 0.92 ABCG2 (0.59) CTSKCTSSSYKABCG2ABCB1
SCHEMBL28736324 0.90 CA12 (0.51) CTSKCTSSSYKCTSLCTSB
SCHEMBL1881253 0.88 CDC7 (0.61) CTSKCTSSSYKCTSLCTSB
SCHEMBL1182188 0.86 NFKB1 (0.58) CTSKCTSSSYKCTSLCTSB
SCHEMBL249084 0.85 SYK (0.49) CTSKCTSSSYKCTSLCTSB
SCHEMBL248043 0.85 PDE4B (0.49) CTSKCTSSSYKCTSLCTSB
SCHEMBL12158707 0.85 JAK2 (0.59) CTSKCTSSSYKCTSLCTSB
SCHEMBL12158629 0.83 ABCB1 (0.62) CTSKCTSSSYKCTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11656384-B2 Composition, film, lens, solid state imaging element, and compounds FUJIFILM CORPORATION (JP) 2023-05-23 US disclosed
US-20200116896-A1 COMPOSITION, FILM, LENS, SOLID STATE IMAGING ELEMENT, AND COMPOUNDS FUJIFILM CORPORATION (JP) 2020-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11656384-B2 Composition, film, lens, solid state imaging element, and compounds UACA, F12, ERGIC1 CTSK 4085/4885CTSS 3943/4885SYK 1111/4885
US-20200116896-A1 COMPOSITION, FILM, LENS, SOLID STATE IMAGING ELEMENT, AND COMPOUNDS UACA, F12, ERGIC1 CTSK 4085/4885CTSS 3943/4885SYK 1111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.