SCHEMBL1741987

SCHEMBL1741987

O=[N+]([O-])c1cc(Cl)ccc1NCC(O)CO

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.54
NPSR1 Q6W5P4 1/20 0.54
MAPT P10636 10/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
TDP1 Q9NUW8 2/20 0.53
POLB P06746 2/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
PKM P14618 2/20 0.48
LMNA P02545 1/20 0.48
HTT P42858 1/20 0.48
APP P05067 1/20 0.47
CYP1A2 P05177 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2C19 P33261 2/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
KCNMA1 Q12791 1/20 0.45
HPGD P15428 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11048215 0.89 MAPT (0.52) ALDH1A1NPSR1MAPTL3MBTL1TDP1
SCHEMBL25341923 0.88 ALDH1A1 (0.53) ALDH1A1NPSR1MAPTL3MBTL1TDP1
SCHEMBL10896768 0.84 MAPT (0.45) ALDH1A1MAPTTDP1POLBMEN1
SCHEMBL10805579 0.84 MAPT (0.62) ALDH1A1NPSR1MAPTL3MBTL1TDP1
SCHEMBL8655505 0.83 KAT2B (0.56) ALDH1A1MAPTL3MBTL1TDP1POLB
SCHEMBL1889528 0.83 PKM (0.45) ALDH1A1MAPTTDP1MEN1KMT2A
SCHEMBL10716987 0.82 MAPT (0.48) ALDH1A1NPSR1MAPTPOLBMEN1
SCHEMBL1136820 0.82 MAPT (0.48) ALDH1A1NPSR1MAPTL3MBTL1POLB
SCHEMBL9657643 0.81 GLA (0.42) ALDH1A1NPSR1MAPTL3MBTL1TDP1
SCHEMBL11772632 0.81 HTT (0.49) ALDH1A1MAPTTDP1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1919439-A2 PROCESS FOR BLEACHING KERATIN FIBERS The Procter and Gamble Company (US) 2008-05-14 EP claimed
US-20070231283-A1 Process for bleaching keratin fibers PROCTER & GAMBLE COMPANY, THE 2007-10-04 US claimed
WO-2007026327-A2 PROCESS FOR BLEACHING KERATIN FIBERS THE PROCTER & GAMBLE COMPANY (US) 2007-03-08 WO claimed
EP-1759684-A1 Process for bleaching keratin fibers Wella Aktiengesellschaft (DE) 2007-03-07 EP claimed
WO-2006108458-A1 AGENTS FOR SIMULTANEOUSLY DYING AND LIGHTENING KERATIN FIBERS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-10-19 WO claimed
US-20050257328-A1 Agent for simultaneously dying and bringhtening keratin fibers WELLA AKTIENGESELLSCHAFT (DE) 2005-11-24 US claimed
EP-2387988-B1 Oxidizing composition for the treatment of keratin fibres PROCTER & GAMBLE (US) 2017-09-27 EP disclosed
US-9499419-B2 Methods and compositions for treatment of skin Special Waters Patents B.V. (NL) 2016-11-22 US disclosed
US-8444706-B2 Oxidizing composition for the treatment of keratin fibers THE PROCTER & GAMBLE COMPANY (US) 2013-05-21 US disclosed
CN-102892402-A Oxidizing composition for the treatment of keratin fibers PROCTER & GAMBLE 2013-01-23 CN disclosed
US-20120288459-A1 Oxidizing Composition for the Treatment of Keratin Fibers BURG WILFRIED (DE) 2012-11-15 US disclosed
US-8308822-B2 Oxidizing composition for the treatment of keratin fibers THE PROCTER & GAMBLE COMPANY (US) 2012-11-13 US disclosed
EP-1972330-B1 Cosmetic or pharmaceutical compositions comprising modified polysiloxanes with at least one carbamate group CLARIANT FINANCE BVI LTD (VG) 2012-09-12 EP disclosed
WO-2005083009-A1 CATIONIC HETEROARYL AZINE DYES, AND DYEING AGENTS CONTAINING SAID COMPOUNDS WELLA AKTIENGESELLSCHAFT (DE) 2005-09-09 WO disclosed
WO-2005079732-A1 HAIR DYE FOR DYEING AND LIGHTENING KERATIN FIBERS WELLA AKTIENGESELLSCHAFT (DE) 2005-09-01 WO disclosed
WO-2005080507-A1 LIGHTENING COLORANT CONTAINING INDOLYL THIAZOLIUM AZO DYES WELLA AKTIENGESELLSCHAFT (DE) 2005-09-01 WO disclosed
WO-2005075574-A1 NEUTRAL AND CATIONIC NAPHTHALENE DERIVATIVES AND DYES CONTAINING SAID COMPOUNDS FOR DYEING KERATIN FIBERS WELLA AKTIENGESELLSCHAFT (DE) 2005-08-18 WO disclosed
WO-2005075481-A1 NOVEL NAPHTHALENE DERIVATIVES AND COLORING AGENTS CONTAINING THESE COMPOUNDS, FOR KERATIN FIBERS WELLA AKTIENGESELLSCHAFT (DE) 2005-08-18 WO disclosed
EP-1555012-A1 Hair dyeing composition containing anthraquinones Clariant GmbH (DE) 2005-07-20 EP disclosed
WO-2004078150-A1 AGENT FOR SIMULTANEOUSLY DYING AND BRIGHTENING KERATIN FIBERS WELLA AKTIENGESELLSCHAFT (DE) 2004-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120288459-A1 Oxidizing Composition for the Treatment of Keratin Fibers KRT18, CKMT1A; CKMT1B, OAT ALDH1A1 1192/4885NPSR1 3480/4885MAPT 1243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.