Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418212 | 0.83 | KCNH2 (0.38) | ALDH1A1KCNH2TMEM97SIGMAR1CSNK2A1 | |
| SCHEMBL29531337 | 0.81 | ALDH1A1 (0.44) | FFAR4ALDH1A1HTR2AMEN1HPGD | |
| SCHEMBL4434656 | 0.81 | ALDH1A1 (0.44) | FFAR4ALDH1A1HTR2AMEN1HPGD | |
| SCHEMBL21598357 | 0.81 | AR (0.38) | FFAR4ALDH1A1KCNH2CSNK2A1HTR2A | |
| SCHEMBL28573110 | 0.80 | CSNK2A1 (0.38) | KCNH2TMEM97SIGMAR1CSNK2A1HTR2A | |
| SCHEMBL3361954 | 0.80 | IRAK4 (0.43) | FFAR4ALDH1A1KCNH2SLC6A4HPGD | |
| SCHEMBL17423620 | 0.79 | MAPK1 (0.40) | ALDH1A1CTSSCTSKMEN1HPGD | |
| SCHEMBL20818373 | 0.78 | CSNK2A1 (0.40) | KCNH2TMEM97SIGMAR1CSNK2A1HTR2A | |
| SCHEMBL20818300 | 0.78 | KCNH2 (0.37) | KCNH2TMEM97SIGMAR1CSNK2A1HTR2A | |
| SCHEMBL21456022 | 0.76 | AGBL2 (0.46) | FFAR4P2RX3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166937-A1 | ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF | Celgene Corporation (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016007848-A1 | ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF | CELGENE CORPORATION (US) | 2016-01-14 | — | — | WO | disclosed |