Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | METAP2 | P50579 | 3/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13923957 | 0.84 | FGFR1 (0.57) | FGFR1LTA4HMETAP2DYRK1ACDK2 | |
| SCHEMBL29644366 | 0.83 | NOS1 (0.47) | FGFR1LMNAMETAP2DYRK1ACDK2 | |
| SCHEMBL26979386 | 0.83 | NOS1 (0.47) | FGFR1LMNAMETAP2DYRK1ACDK2 | |
| SCHEMBL17423777 | 0.80 | LMNA (0.59) | LMNATDP1LTA4HCYP19A1MEN1 | |
| SCHEMBL2933092 | 0.75 | NR4A1 (0.55) | FGFR1LMNATDP1METAP2DYRK1A | |
| SCHEMBL16114401 | 0.74 | LMNA (0.75) | LMNATDP1LTA4HCYP19A1HTT | |
| SCHEMBL30535283 | 0.74 | LMNA (0.82) | LMNATDP1LTA4HCYP19A1HTT | |
| SCHEMBL676142 | 0.74 | LMNA (0.82) | LMNATDP1LTA4HCYP19A1HTT | |
| SCHEMBL2540132 | 0.74 | LMNA (0.59) | LMNATDP1LTA4HCYP19A1HTT | |
| SCHEMBL17423760 | 0.74 | LMNA (0.54) | LMNATDP1LTA4HCYP19A1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |