Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.34 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099517 | 0.89 | L3MBTL1 (0.45) | KMT2AL3MBTL1LMNAMEN1SMN1; SMN2 | |
| SCHEMBL10667184 | 0.71 | NPSR1 (0.74) | KMT2AKDM4EL3MBTL1CHRM5CHKA | |
| SCHEMBL17459987 | 0.71 | NPSR1 (0.54) | KMT2AKDM4EL3MBTL1CHRM5CHKA | |
| SCHEMBL2481899 | 0.70 | NPSR1 (0.46) | KMT2AL3MBTL1LMNAMEN1NPSR1 | |
| SCHEMBL10668893 | 0.69 | NPSR1 (0.57) | KMT2AKDM4EL3MBTL1LMNACHRM5 | |
| SCHEMBL10669575 | 0.69 | NPSR1 (0.52) | KMT2AKDM4ELMNACHRM5MEN1 | |
| SCHEMBL174242 | 0.69 | KDM4E (0.50) | KMT2AKDM4EL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL18929814 | 0.69 | TAAR1 (0.47) | KMT2AKDM4ELMNACHRM5CHKA | |
| SCHEMBL3400124 | 0.69 | NPSR1 (0.44) | KMT2AL3MBTL1LMNAMEN1NPSR1 | |
| SCHEMBL5961422 | 0.69 | ALDH1A1 (0.46) | KMT2AKDM4EL3MBTL1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103261160-A | guanidine compounds and compositions for inhibition of NAMPT | FORMA THERAPEUTICS INC | 2013-08-21 | — | — | CN | claimed |
| EP-2611778-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012031199-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | claimed |
| CN-103261160-A | guanidine compounds and compositions for inhibition of NAMPT | FORMA THERAPEUTICS INC | 2013-08-21 | — | — | CN | disclosed |
| EP-2611778-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031199-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |