Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18929814 | 0.93 | TAAR1 (0.47) | KDM4EKMT2ATAAR1TYK2JAK2 | |
| SCHEMBL9113008 | 0.88 | HTT (0.49) | KMT2AHTTSMN1; SMN2LMNACA9 | |
| SCHEMBL7680708 | 0.80 | HTT (0.46) | KMT2AHTTSMN1; SMN2LMNACA9 | |
| SCHEMBL11836946 | 0.72 | LMNA (0.48) | KDM4EKMT2AHTTPOLBLMNA | |
| SCHEMBL7421824 | 0.71 | LMNA (0.47) | KDM4EKMT2AHTTPOLBLMNA | |
| SCHEMBL10536719 | 0.70 | TAAR1 (0.61) | KDM4EKMT2ATAAR1TYK2JAK2 | |
| SCHEMBL2001630 | 0.70 | TAS2R38 (0.46) | KMT2ATAAR1SMN1; SMN2POLBRAB9A | |
| SCHEMBL5779983 | 0.69 | JAK2 (0.61) | KDM4EKMT2ATAAR1TYK2JAK2 | |
| SCHEMBL4979740 | 0.69 | NOX1 (0.64) | KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL174243 | 0.69 | KMT2A (0.41) | KDM4EKMT2ATAAR1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103261160-A | guanidine compounds and compositions for inhibition of NAMPT | FORMA THERAPEUTICS INC | 2013-08-21 | — | — | CN | claimed |
| EP-2611778-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012031199-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | claimed |
| CN-103261160-A | guanidine compounds and compositions for inhibition of NAMPT | FORMA THERAPEUTICS INC | 2013-08-21 | — | — | CN | disclosed |
| EP-2611778-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031199-A1 | GUANIDINE COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |