Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2272546 | 0.91 | ENPP2 (0.33) | ENPP2FGFR1FGFR3FGFR2FGFR4 | |
| SCHEMBL2223471 | 0.86 | ENPP2 (0.33) | ENPP2FGFR1FGFR3FGFR2FGFR4 | |
| SCHEMBL2221804 | 0.81 | ENPP2 (0.35) | ENPP2FGFR1FGFR3EGLN1MET | |
| SCHEMBL2272785 | 0.81 | ENPP2 (0.35) | ENPP2FGFR1FGFR3FGFR2FGFR4 | |
| SCHEMBL13275143 | 0.81 | OXTR (0.33) | OXTRPPARGPPARAEGLN1HSD17B10 | |
| SCHEMBL2334239 | 0.80 | ENPP2 (0.34) | ENPP2FGFR1FGFR3PPARGPPARA | |
| SCHEMBL2270206 | 0.80 | MERTK (0.32) | ENPP2EGLN1MET | |
| SCHEMBL13275265 | 0.80 | DGAT1 (0.34) | ENPP2PPARGPPARA | |
| SCHEMBL13275446 | 0.79 | RAB9A (0.37) | ENPP2EGLN1 | |
| SCHEMBL2221942 | 0.79 | ENPP2 (0.35) | ENPP2FGFR1FGFR3EGLN1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611450-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030633-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-03-08 | — | — | WO | disclosed |