Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17310231 | 0.80 | LRRK2 (0.62) | PIK3CAMAPK13LRRK2CYP2C19PIK3CD | |
| SCHEMBL28664080 | 0.79 | PIK3CA (0.54) | PIK3CAMAPK13LRRK2CYP2C19KMO | |
| SCHEMBL15145216 | 0.78 | PIK3CA (0.63) | PIK3CAMAPK13LRRK2CYP2C19KMO | |
| SCHEMBL19034812 | 0.77 | PIK3CA (0.57) | PIK3CAMAPK13LRRK2CYP2C19KMO | |
| SCHEMBL247930 | 0.76 | PIK3CA (0.64) | PIK3CAMAPK13LRRK2CYP2C19KMO | |
| SCHEMBL171298 | 0.75 | MAPK13 (0.55) | PIK3CAMAPK13LRRK2CYP2C19PIK3CD | |
| SCHEMBL16021772 | 0.73 | ALDH1A1 (0.47) | PIK3CAPIK3CDHTTSMN1; SMN2KDM4E | |
| SCHEMBL27936855 | 0.73 | LRRK2 (0.59) | PIK3CALRRK2CYP2C19KMOPIK3CD | |
| SCHEMBL12639899 | 0.72 | PIK3CA (0.76) | PIK3CAMAPK13KMOKDM4EALDH1A1 | |
| SCHEMBL18616062 | 0.71 | LRRK2 (0.59) | PIK3CAMAPK13LRRK2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230148450-A9 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | Revolution Medicines, Inc. | 2023-05-11 | — | — | US | disclosed |
| US-9718818-B2 | Compounds inhibiting leucine-rich repeat kinase enzyme activity | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | disclosed |
| US-9688654-B2 | Compounds inhibiting leucine-rich repeat kinase enzyme activity | MERCK SHARP & DOHME CORP. (US) | 2017-06-27 | — | — | US | disclosed |
| US-9440952-B2 | Compounds inhibiting leucine-rich repeat kinase enzyme activity | MERCK SHARP & DOHME CORP. (US) | 2016-09-13 | — | — | US | disclosed |
| US-20160200722-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160009681-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME LLC | 2016-01-14 | — | — | US | disclosed |
| US-20160009682-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME LLC | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200722-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | LRRK2, LRRC47, LMTK2 | PIK3CA 869/4885MAPK13 392/4885LRRK2 1/4885 |
| US-20160009682-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | LRRK2, LRRC47, LIMK2 | PIK3CA 752/4885MAPK13 410/4885LRRK2 1/4885 |
| US-20230148450-A9 | BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF | SOST, SOS1, SOS2 | PIK3CA 445/4885MAPK13 1647/4885LRRK2 497/4885 |
| US-20160009681-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | LRRK2, PARK7, PINK1 | PIK3CA 764/4885MAPK13 322/4885LRRK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.