Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 4/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.31 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19088918 | 0.93 | PDE4D (0.34) | PDE4DCTSKCNR2CNR1TAS1R3 | |
| SCHEMBL17898767 | 0.90 | PDE4D (0.33) | PDE4DTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL17427125 | 0.89 | PDE4D (0.33) | PDE4DCNR2RIPK1TAS1R3TAS1R1 | |
| SCHEMBL19084190 | 0.89 | TAS1R3 (0.35) | CNR2TAS1R3TAS1R1TAS1R2PDE10A | |
| SCHEMBL19088919 | 0.87 | PDE4D (0.34) | PDE4DCTSKCNR2CNR1TAS1R3 | |
| SCHEMBL17427102 | 0.87 | PDE4D (0.33) | PDE4DRIPK1 | |
| SCHEMBL17428168 | 0.87 | — | — | |
| SCHEMBL17417044 | 0.86 | RIPK1 (0.36) | PDE4DRIPK1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL19628457 | 0.86 | PDE4D (0.33) | PDE4DCTSKCNR2TAS1R3TAS1R1 | |
| SCHEMBL17418875 | 0.85 | F2R (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170273303-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CORTEVA AGRISCIENCE LLC | 2017-09-28 | — | — | US | disclosed |
| US-20170273303-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CORTEVA AGRISCIENCE LLC | 2017-09-28 | — | — | US | disclosed |
| US-9686984-B2 | Macrocyclic picolinamides as fungicides | DOW AGROSCIENCES LLC (US) | 2017-06-27 | — | — | US | disclosed |
| US-9686984-B2 | Macrocyclic picolinamides as fungicides | DOW AGROSCIENCES LLC (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160007602-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC | 2016-01-14 | — | — | US | disclosed |
| US-20160007602-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC | 2016-01-14 | — | — | US | disclosed |
| WO-2016007531-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2016-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170273303-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CYP4F12, CYP1A2, FKBP2 | PDE4D 2017/4885CTSK 2613/4885CNR2 2355/4885 |
| US-20160007602-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CYP4F12, CYP1A2, FKBP2 | PDE4D 2017/4885CTSK 2613/4885CNR2 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.