Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 6/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.35 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.35 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.35 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.35 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.35 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.35 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.35 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17431782 | 0.89 | HSD11B1 (0.55) | HSD11B1HSD11B2ACHEPRKAG1PRKAA2 | |
| SCHEMBL13642557 | 0.82 | GPBAR1 (0.48) | TOP2ATOP2BNR1H4 | |
| SCHEMBL13642752 | 0.82 | GPBAR1 (0.48) | TOP2ATOP2BNR1H4 | |
| SCHEMBL13642588 | 0.80 | HSD11B1 (0.62) | HSD11B1HSD11B2ACHEPRKAG1PRKAA2 | |
| SCHEMBL13642319 | 0.80 | HSD11B1 (0.62) | HSD11B1HSD11B2ACHEPRKAG1PRKAA2 | |
| SCHEMBL13642791 | 0.79 | GPBAR1 (0.43) | TOP2ATOP2BATP1A1ATP1B1ATP1A3 | |
| SCHEMBL13642612 | 0.79 | GPBAR1 (0.43) | TOP2ATOP2BATP1A1ATP1B1ATP1A3 | |
| SCHEMBL13642514 | 0.79 | GPBAR1 (0.43) | TOP2ATOP2BATP1A1ATP1B1ATP1A3 | |
| SCHEMBL13642524 | 0.78 | PTPN1 (0.33) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL13642560 | 0.78 | PTPN1 (0.33) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522935-B2 | Commands and method of treating cancer via RHO pathway | DM INTELLIGENCE MEDICINE LTD (CN) | 2016-12-20 | — | — | US | disclosed |
| US-20160009756-A1 | Commands and method of treating cancer via RHO pathway | Xie, Weidong (CA) | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009756-A1 | Commands and method of treating cancer via RHO pathway | RHOA, RHOT2, ROCK1 | HSD11B1 243/4885HSD11B2 441/4885ACHE 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.