Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | TOP2A | P11388 | 5/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | CRYAA | P02489 | 1/20 | 0.41 |
| ▸ | CRYAB | P02511 | 1/20 | 0.41 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17428529 | 0.89 | HSD11B1 (0.44) | HSD11B1HSD11B2ACHEPRKAG1PRKAA2 | |
| SCHEMBL15233192 | 0.86 | SLC10A1 (0.42) | HSD11B1HSD11B2ACHEPTPN1TOP2A | |
| SCHEMBL16488039 | 0.86 | SLC10A1 (0.42) | HSD11B1HSD11B2ACHEPTPN1TOP2A | |
| SCHEMBL28831684 | 0.84 | HMGCR (0.54) | HMGCRSLC10A1ACLYACACA | |
| SCHEMBL4104338 | 0.82 | HMGCR (0.44) | PTPN1TOP2AHMGCRCRYAACRYAB | |
| SCHEMBL24285051 | 0.82 | ACLY (0.54) | ACHEPTPN1TOP2AHMGCRCRYAB | |
| 3Beta,24,25-Trihydroxycycloartane SCHEMBL3306653 | 0.80 | HSD11B1 (0.76) | HSD11B1HSD11B2ACHEPRKAG1PRKAA2 | |
| SCHEMBL3303674 | 0.75 | TOP2A (0.63) | HSD11B1HSD11B2ACHEPRKAG1PRKAA2 | |
| SCHEMBL3303672 | 0.75 | TOP2A (0.63) | HSD11B1HSD11B2ACHEPRKAG1PRKAA2 | |
| SCHEMBL1878450 | 0.73 | HSD11B1 (0.56) | HSD11B1HSD11B2ACHEPRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522935-B2 | Commands and method of treating cancer via RHO pathway | DM INTELLIGENCE MEDICINE LTD (CN) | 2016-12-20 | — | — | US | disclosed |
| US-20160009756-A1 | Commands and method of treating cancer via RHO pathway | Xie, Weidong (CA) | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009756-A1 | Commands and method of treating cancer via RHO pathway | RHOA, RHOT2, ROCK1 | HSD11B1 243/4885HSD11B2 441/4885ACHE 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.