Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 14/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1744608 | 0.80 | SLC6A2 (0.46) | MAOAMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1742890 | 0.78 | MAPT (0.43) | MAOAMAPTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1742889 | 0.74 | GPBAR1 (0.44) | MAOAMAOBP2RX7SMN1; SMN2LMNA | |
| SCHEMBL1745461 | 0.73 | ESR1 (0.45) | MAOBSMN1; SMN2LMNAMAPTSLC6A2 | |
| SCHEMBL8602640 | 0.63 | KMT2A (0.64) | MAOAMAPT | |
| SCHEMBL30539980 | 0.62 | ROCK2 (0.62) | ROCK2ROCK1P2RX7ALDH1A1SMN1; SMN2 | |
| SCHEMBL9016177 | 0.62 | ROCK2 (0.62) | ROCK2ROCK1P2RX7ALDH1A1SMN1; SMN2 | |
| SCHEMBL19852901 | 0.62 | ROCK2 (0.62) | ROCK2ROCK1P2RX7SMN1; SMN2LMNA | |
| SCHEMBL5698943 | 0.62 | P2RX7 (0.52) | ROCK2ROCK1P2RX7ALDH1A1SMN1; SMN2 | |
| SCHEMBL29566137 | 0.62 | P2RX7 (0.52) | ROCK2ROCK1P2RX7ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387560-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2011-11-23 | — | — | EP | claimed |
| US-8042193-B1 | Systems and methods for controlling data access by use of a universal anonymous identifier | Albright Associates (US) | 2011-10-18 | — | — | US | claimed |
| WO-2010083441-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-07-22 | — | — | WO | claimed |