Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | GLI1 | P08151 | 1/20 | 0.38 |
| ▸ | GLI2 | P10070 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742890 | 0.91 | MAPT (0.43) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A | |
| SCHEMBL1745461 | 0.88 | ESR1 (0.45) | SLC6A2SLC6A4SLC6A3CTNNB1WNT3A | |
| SCHEMBL1742891 | 0.80 | MAOA (0.40) | SLC6A2SLC6A4SLC6A3MAPTMAOA | |
| SCHEMBL1744461 | 0.75 | HSD11B1 (0.42) | MAPTHSD11B1DRD2DRD3 | |
| SCHEMBL2480796 | 0.75 | BCL2 (0.45) | — | |
| SCHEMBL1354825 | 0.72 | TDP1 (0.50) | CTNNB1WNT3ANPC1MAOALTA4H | |
| SCHEMBL8602640 | 0.72 | KMT2A (0.64) | CTNNB1WNT3ANPC1MAPTRAB9A | |
| SCHEMBL6236597 | 0.68 | BCAT1 (0.51) | NPC1MAPTRAB9AMAOA | |
| SCHEMBL2535060 | 0.68 | NPC1 (0.51) | CTNNB1WNT3ANPC1MAPTRAB9A | |
| SCHEMBL16741838 | 0.67 | AKR1C3 (0.59) | CTNNB1WNT3ANPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387560-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2011-11-23 | — | — | EP | claimed |
| US-8042193-B1 | Systems and methods for controlling data access by use of a universal anonymous identifier | Albright Associates (US) | 2011-10-18 | — | — | US | claimed |
| WO-2010083441-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-07-22 | — | — | WO | claimed |