Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.52 |
| ▸ | PRKCG | P05129 | 5/20 | 0.52 |
| ▸ | PRKCB | P05771 | 5/20 | 0.52 |
| ▸ | PRKCA | P17252 | 5/20 | 0.52 |
| ▸ | PRKCH | P24723 | 5/20 | 0.52 |
| ▸ | PRKCI | P41743 | 5/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9016177 | 0.84 | ROCK2 (0.62) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL30539980 | 0.84 | ROCK2 (0.62) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL9541258 | 0.80 | FLT3 (0.62) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL10979885 | 0.77 | ROCK2 (0.55) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL20873436 | 0.76 | PRKCG (0.67) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL10496395 | 0.76 | FLT3 (0.55) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL4729399 | 0.76 | PRKD3 (0.57) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL13677595 | 0.76 | CYP3A4 (0.58) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL9543879 | 0.75 | PRKACA (0.63) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL6967362 | 0.75 | CYP3A4 (0.59) | ROCK2ROCK1PRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | IOMET PHARMA LTD. (GB) | 2019-05-14 | — | — | US | disclosed |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD. (GB) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | TDO2, IDO2, IDO1 | ROCK2 727/4885ROCK1 1270/4885PRKD3 2755/4885 |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | TDO2, IDO2, IDO1 | ROCK2 727/4885ROCK1 1270/4885PRKD3 2755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.