Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17429599 | 0.81 | ALOX15 (0.41) | HTTHIF1ACYP3A4MEN1HPGD | |
| SCHEMBL17429590 | 0.81 | MAPT (0.44) | HTTHIF1ACYP3A4MEN1HPGD | |
| SCHEMBL17740977 | 0.81 | ALOX15 (0.38) | HTTHIF1ACYP3A4HPGDKMT2A | |
| SCHEMBL30253993 | 0.81 | ALOX15 (0.38) | HTTHIF1ACYP3A4HPGDKMT2A | |
| SCHEMBL17429589 | 0.79 | HPGD (0.36) | HTTHIF1ACYP3A4MEN1HPGD | |
| SCHEMBL18291895 | 0.75 | MEN1 (0.35) | HTTHIF1ACYP3A4MEN1HPGD | |
| SCHEMBL17429601 | 0.72 | ALDH1A1 (0.37) | HIF1ACYP3A4HPGDALOX15MAPT | |
| SCHEMBL29761218 | 0.69 | KEAP1 (0.50) | HTTHIF1ACYP3A4MEN1HPGD | |
| SCHEMBL1614038 | 0.69 | KEAP1 (0.50) | HTTHIF1ACYP3A4MEN1HPGD | |
| SCHEMBL27033373 | 0.69 | MAPT (0.39) | HTTHIF1ACYP3A4MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202401-B2 | Process for making tetracyclic heterocycle compounds | MSD R&D CN CO., LTD (CN) | 2019-02-12 | — | — | US | disclosed |
| US-10202401-B2 | Process for making tetracyclic heterocycle compounds | MSD R&D CN CO., LTD (CN) | 2019-02-12 | — | — | US | disclosed |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARPE & DOHME CORP. (US) | 2018-03-08 | — | — | US | disclosed |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARPE & DOHME CORP. (US) | 2018-03-08 | — | — | US | disclosed |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARPE & DOHME CORP. (US) | 2018-03-08 | — | — | US | disclosed |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MSD R&D (CHINA) CO., LTD (CN) | 2017-06-15 | — | — | US | disclosed |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MSD R&D (CHINA) CO., LTD (CN) | 2017-06-15 | — | — | US | disclosed |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MSD R&D (CHINA) CO., LTD (CN) | 2017-06-15 | — | — | US | disclosed |
| WO-2016004899-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202401-B2 | Process for making tetracyclic heterocycle compounds | CYP1B1, CYP1A2, CYP2F1 | HTT 626/4885HIF1A 2293/4885CYP3A4 7/4885 |
| US-20170166586-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | CYP1A2, CYP3A5, CYP1B1 | HTT 503/4885HIF1A 2472/4885CYP3A4 6/4885 |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | CYP1B1, CYP1A2, CYP2F1 | HTT 626/4885HIF1A 2293/4885CYP3A4 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.