Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17429775 | 1.00 | TRPA1 (0.55) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL15576823 | 0.88 | TRPA1 (0.67) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL10112083 | 0.86 | TRPA1 (0.50) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL12153269 | 0.86 | TRPA1 (0.50) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL12727375 | 0.86 | TRPA1 (0.50) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL26085425 | 0.85 | TRPA1 (0.61) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL26085426 | 0.85 | TRPA1 (0.61) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL873142 | 0.85 | TRPA1 (0.61) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL3245861 | 0.84 | SIGMAR1 (0.58) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL105769 | 0.81 | TRPA1 (0.57) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170273303-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CORTEVA AGRISCIENCE LLC | 2017-09-28 | — | — | US | disclosed |
| US-9686984-B2 | Macrocyclic picolinamides as fungicides | DOW AGROSCIENCES LLC (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160007602-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170273303-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CYP4F12, CYP1A2, FKBP2 | TRPA1 676/4885TAAR1 3746/4885SIGMAR1 1586/4885 |
| US-20160007602-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CYP4F12, CYP1A2, FKBP2 | TRPA1 676/4885TAAR1 3746/4885SIGMAR1 1586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.