SCHEMBL174300

SCHEMBL174300

Cc1cc(OCCOCCOCCC(F)(F)P(=O)(O)O)ccc1CCc1cnc2c(N)nc3cc(CCC(=O)O)ccc3c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL174281 1.00 TLR7 (1.00) TLR7
SCHEMBL29413224 1.00 TLR7 (1.00) TLR7
SCHEMBL30575423 1.00 TLR7 (1.00) TLR7
SCHEMBL29454511 1.00 TLR7 (1.00) TLR7
SCHEMBL16751867 0.98 TLR7 (0.96) TLR7
SCHEMBL17874536 0.95 TLR7 (0.91) TLR7
SCHEMBL17874538 0.95 TLR7 (0.91) TLR7
SCHEMBL173576 0.94 TLR7 (1.00) TLR7
SCHEMBL30575426 0.94 TLR7 (1.00) TLR7
SCHEMBL27048224 0.93 TLR7 (0.86) TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240009215-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION NOVARTIS AG (CH) 2024-01-11 US claimed
US-11752162-B2 Compounds and compositions for treating solid tumors by intratumoral administration NOVARTIS AG (CH) 2023-09-12 US claimed
US-20210154214-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. DBA THE GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION 2021-05-27 US claimed
EP-3624806-A1 COMPOSITIONS COMPRISING NAPHTHYRIDINE DERIVATIVES AND ALUMINIUM ADJUVANT FOR USE IN TREATING SOLID TUMORS Novartis AG (CH) 2020-03-25 EP claimed
WO-2018211453-A1 COMPOSITIONS COMPRISING NAPHTHYRIDINE DERIVATIVES AND ALUMINIUM ADJUVANT FOR USE IN TREATING SOLID TUMORS NOVARTIS AG (CH) 2018-11-22 WO claimed
US-9950062-B2 Compounds and compositions as TLR activity modulators GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2018-04-24 US claimed
EP-2440245-B1 BENZONAPHTHYRIDINE-CONTAINING VACCINES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2017-12-06 EP claimed
EP-2473508-B1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2017-03-08 EP claimed
US-9517263-B2 Benzonaphthyridine-containing vaccines GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-12-13 US claimed
US-9045470-B2 Compounds and compositions as TLR activity modulators IRM LLC (BM) 2015-06-02 US claimed
EP-2459216-B1 IMMUNOGENIC COMPOSITIONS INCLUDING TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2013-10-30 EP claimed
US-20120263753-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES NOVARTIS AG (CH) 2012-10-18 US claimed
US-20120237546-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2012-09-20 US claimed
EP-2473508-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2012-07-11 EP claimed
EP-2459216-A2 IMMUNOGENIC COMPOSITIONS INCLUDING TLR ACTIVITY MODULATORS Novartis AG (CH) 2012-06-06 EP claimed
EP-2440245-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES Novartis AG (CH) 2012-04-18 EP claimed
WO-2011049677-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-04-28 WO claimed
WO-2011027222-A2 IMMUNOGENIC COMPOSITIONS INCLUDING TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2011-03-10 WO claimed
US-20110053893-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-03-03 US claimed
WO-2010144734-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES NOVARTIS AG (CH) 2010-12-16 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210154214-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION TLR7, TLR9, TLR3 TLR7 1/4885
US-20120263753-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES LY96, TLR3, GABRA4 TLR7 7/4885
US-11752162-B2 Compounds and compositions for treating solid tumors by intratumoral administration TLR7, TLR9, TLR3 TLR7 1/4885
US-20120237546-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS TLR1, TLR6, TLR7 TLR7 3/4885
US-20110053893-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS TLR1, TLR6, TLR7 TLR7 3/4885
US-20240009215-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION TLR7, TLR9, TLR3 TLR7 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.