Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.56 |
| ▸ | PYGL | P06737 | 4/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30762244 | 0.92 | NPC1 (0.57) | KMT2AMEN1RXFP1NPC1LMNA | |
| SCHEMBL17422865 | 0.92 | NPC1 (0.57) | KMT2AMEN1RXFP1NPC1LMNA | |
| SCHEMBL29176363 | 0.86 | NPC1 (0.71) | NPC1LMNARAB9ASMN1; SMN2EGFR | |
| SCHEMBL29176325 | 0.86 | NHERF1 (0.56) | KMT2AMEN1RXFP1NHERF1PYGL | |
| SCHEMBL29176354 | 0.82 | NPC1 (0.58) | KMT2AMEN1NHERF1ALOX15NPC1 | |
| SCHEMBL16627058 | 0.82 | NPC1 (0.78) | KMT2AMEN1RXFP1NHERF1PYGL | |
| SCHEMBL17433428 | 0.79 | NPC1 (0.78) | NPC1LMNARAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20596831 | 0.78 | ROCK2 (0.52) | NPC1LMNARAB9ASMN1; SMN2PRMT1 | |
| SCHEMBL30571090 | 0.78 | ROCK2 (0.52) | NPC1LMNARAB9ASMN1; SMN2PRMT1 | |
| SCHEMBL29176334 | 0.78 | NPC1 (0.52) | KMT2AMEN1ALOX15NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170216252-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS | SIMON FRASER UNIVERSITY (CA) | 2017-08-03 | — | — | US | disclosed |
| US-20170216252-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS | SIMON FRASER UNIVERSITY (CA) | 2017-08-03 | — | — | US | disclosed |
| WO-2016004513-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS | SIMON FRASER UNIVERSITY (CA) | 2016-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170216252-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS | PDK1, PDK3, PDK2 | KMT2A 2483/4885MEN1 4611/4885RXFP1 2175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.