Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.41 |
| ▸ | PDE4A | P27815 | 10/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17434268 | 0.83 | PDE5A (0.39) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17434544 | 0.80 | PDE5A (0.50) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17434110 | 0.78 | EEF2K (0.49) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL17434603 | 0.75 | NOTUM (0.41) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17434081 | 0.73 | EEF2K (0.39) | NOTUMPIK3CAMTOR | |
| SCHEMBL16092737 | 0.70 | RORC (0.53) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29203442 | 0.70 | KDM4C (0.42) | PTGER4MEN1KMT2A | |
| SCHEMBL17434214 | 0.70 | PARG (0.41) | NOTUMPIK3CAKDM4EMEN1LMNA | |
| SCHEMBL7145632 | 0.69 | ALDH1A1 (0.60) | NOTUMKDM4EMEN1LMNAPOLB | |
| SCHEMBL6529188 | 0.69 | TP53 (0.52) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834520-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-12-05 | — | — | US | disclosed |
| US-20160229814-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-08-11 | — | — | US | disclosed |
| EP-2975031-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2016-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229814-A1 | HETEROCYCLIC COMPOUND | RORB, RORC, RORA | PDE5A 1774/4885PDE4A 2341/4885PDE4B 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.