Sugi Predict

Sugi Predict / Compounds / SCHEMBL17434530

SCHEMBL17434530

SCHEMBL17434530

Cc1c(C#N)cc2[nH]c3c(c2c1C)C(=O)c1ccccc1C3

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP8 P40818 1/20 0.37
▸ USP7 Q93009 1/20 0.37
▸ MAOA P21397 1/20 0.36
▸ ALDH1A1 P00352 5/20 0.34
▸ KDM4E B2RXH2 3/20 0.34
▸ GALR3 O60755 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ BCHE P06276 1/20 0.34
▸ CES1 P23141 1/20 0.34
▸ CHEK1 O14757 1/20 0.34
▸ WEE1 P30291 1/20 0.34
▸ ACHE P22303 1/20 0.33
▸ GRIN2D O15399 1/20 0.32
▸ GRIN3B O60391 1/20 0.32
▸ GRIN1 Q05586 1/20 0.32
▸ GRIN2A Q12879 1/20 0.32
▸ GRIN2B Q13224 1/20 0.32
▸ GRIN2C Q14957 1/20 0.32
▸ GRIN3A Q8TCU5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15821395 0.72 FLT3 (0.47) CCNB2CDK1CCNB1CCNA2CDK2
SCHEMBL29818492 0.72 FLT3 (0.47) CCNB2CDK1CCNB1CCNA2CDK2
SCHEMBL27583056 0.70 USP8 (0.59) USP8USP7ALDH1A1KDM4EGALR3
SCHEMBL29940783 0.69 CA1 (0.50) MAOAALDH1A1KDM4EGAAHPGD
SCHEMBL9526776 0.68 ADORA3 (0.43) ALDH1A1GAACHEK1WEE1PARP1
SCHEMBL28571180 0.67 MAOA (0.55) USP8USP7MAOAALDH1A1KDM4E
SCHEMBL7340522 0.66 KDM4E (0.49) USP8USP7MAOAALDH1A1KDM4E
SCHEMBL9526783 0.66 DRD1 (0.33) PARP1
SCHEMBL15960870 0.63 MAOA (0.53) MAOAALDH1A1KDM4EGAABCHE
SCHEMBL31589075 0.63 MAOA (0.53) MAOAALDH1A1KDM4EGAABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250064837-A1 TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEIR INTERMEDIATES AND USE OF INTERMEDIATES SHANGHAITECH UNIVERSITY (CN) 2025-02-27 — — US disclosed
US-12226424-B2 Target protein degradation compounds, their anti-tumor use, their intermediates and use of intermediates SHANGHAITECH UNIVERSITY (CN) 2025-02-18 — — US disclosed
US-20220117982-A1 TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEIR INTERMEDIATES AND USE OF INTERMEDIATES SHANGHAITECH UNIVERSITY (CN) 2022-04-21 — — US disclosed
EP-2975024-A1 TETRACYCLIC COMPOUNDS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-01-20 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250064837-A1 TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEIR INTERMEDIATES AND USE OF INTERMEDIATES UFM1, SUMO1, SUMO2 USP8 48/4885USP7 77/4885MAOA 3461/4885
US-12226424-B2 Target protein degradation compounds, their anti-tumor use, their intermediates and use of intermediates UFM1, SUMO1, SUMO2 USP8 53/4885USP7 85/4885MAOA 3567/4885
US-20220117982-A1 TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEIR INTERMEDIATES AND USE OF INTERMEDIATES UFM1, SUMO1, SUMO2 USP8 53/4885USP7 85/4885MAOA 3567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.