Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 13/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2380277 | 0.77 | OPRL1 (0.55) | OPRM1OPRL1SLC22A1OPRK1 | |
| SCHEMBL2380279 | 0.77 | OPRL1 (0.55) | OPRM1OPRL1SLC22A1OPRK1 | |
| SCHEMBL17443953 | 0.73 | OPRM1 (0.48) | OPRM1OPRL1OPRK1GAA | |
| SCHEMBL13650545 | 0.70 | OPRM1 (0.57) | OPRM1OPRL1SLC22A1OPRK1 | |
| SCHEMBL2200217 | 0.65 | OPRM1 (0.54) | OPRM1OPRL1OPRK1 | |
| SCHEMBL13650546 | 0.65 | L3MBTL1 (0.52) | OPRM1OPRL1SLC22A1OPRK1 | |
| SCHEMBL3407202 | 0.65 | OPRM1 (0.43) | OPRM1OPRL1SLC6A4GAA | |
| SCHEMBL2379490 | 0.64 | OPRL1 (0.54) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL2379486 | 0.63 | OPRL1 (0.56) | OPRM1OPRL1OPRK1 | |
| SCHEMBL7408742 | 0.63 | L3MBTL1 (0.43) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202345-B2 | Substituted azaspiro(4.5)decane derivatives | GRUENENTHAL GMBH (DE) | 2019-02-12 | — | — | US | disclosed |
| US-20160016903-A1 | Substituted Azaspiro(4.5)Decane Derivatives | GRUENENTHAL GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202345-B2 | Substituted azaspiro(4.5)decane derivatives | OPRL1, OPRD1, OPRM1 | OPRM1 3/4885OPRL1 1/4885SLC22A1 3074/4885 |
| US-20160016903-A1 | Substituted Azaspiro(4.5)Decane Derivatives | OPRL1, OPRD1, OPRM1 | OPRM1 3/4885OPRL1 1/4885SLC22A1 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.