Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL30899743 | 1.00 | TSHR (0.50) | TSHRTHRBMEN1KMT2ANFKB1 | |
| Tartaric Acid SCHEMBL30276688 | 1.00 | TSHR (0.50) | TSHRTHRBMEN1KMT2ANFKB1 | |
| Cadaverine Tartrate SCHEMBL5804440 | 1.00 | TSHR (0.50) | TSHRTHRBMEN1KMT2ANFKB1 | |
| Cadaverine Tartrate SCHEMBL1155812 | 1.00 | TSHR (0.50) | TSHRTHRBMEN1KMT2ANFKB1 | |
| Cadaverine Tartrate SCHEMBL918361 | 1.00 | TSHR (0.50) | TSHRTHRBMEN1KMT2ANFKB1 | |
| Cadaverine Tartrate SCHEMBL30899742 | 1.00 | TSHR (0.50) | TSHRTHRBMEN1KMT2ANFKB1 | |
| Cadaverine Tartrate SCHEMBL2998062 | 0.83 | TSHR (0.48) | TSHRNFKB1CYP2C19MMP2MMP1 | |
| SCHEMBL11367816 | 0.83 | THRB (0.48) | THRBMEN1KMT2AMMP2MMP9 | |
| Cadaverine Tartrate SCHEMBL30432913 | 0.81 | THRB (0.46) | TSHRTHRBMEN1KMT2AMMP2 | |
| SCHEMBL8939281 | 0.81 | THRB (0.46) | THRBMEN1KMT2AMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2977368-B1 | METHOD FOR PRODUCING OPTICALLY ACTIVE TRANS-1,2-DIAMINOCYCLOHEXANE | TORAY FINECHEMICALS CO LTD (JP) | 2019-06-12 | — | — | EP | disclosed |
| EP-2977368-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE TRANS-1,2-DIAMINOCYCLOHEXANE | Toray Fine Chemicals Co., Ltd. (JP) | 2016-01-27 | — | — | EP | disclosed |
| US-20160016885-A1 | METHOD OF PRODUCING OPTICALLY ACTIVE TRANS-1,2-DIAMINOCYCLOHEXANE | TORAY FINE CHEMICALS CO., LTD. (JP) | 2016-01-21 | — | — | US | disclosed |