Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | TK1 | P04183 | 4/20 | 0.38 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.36 |
| ▸ | DUT | P33316 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | TK2 | O00142 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856058 | 1.00 | KIF11 (0.41) | KIF11TK1CYP24A1DUTCTSK | |
| SCHEMBL14856176 | 1.00 | KIF11 (0.41) | KIF11TK1CYP24A1DUTCTSK | |
| SCHEMBL537529 | 0.83 | RXRA (0.39) | ALDH1A1 | |
| SCHEMBL27444624 | 0.80 | ALDH1A1 (0.34) | CYP24A1ALDH1A1CHRM2CHRM1CHRM3 | |
| SCHEMBL20583464 | 0.79 | ALDH1A1 (0.39) | TK1ALDH1A1KMT2A | |
| SCHEMBL20583462 | 0.79 | ALDH1A1 (0.39) | TK1ALDH1A1KMT2A | |
| SCHEMBL2920196 | 0.79 | CYP2D6 (0.38) | KIF11TK1CYP24A1DUTCTSK | |
| SCHEMBL14538220 | 0.79 | KIF11 (0.46) | KIF11TK1DUTCTSKALDH1A1 | |
| SCHEMBL28353232 | 0.78 | SLC6A11 (0.44) | KIF11ALDH1A1KMT2A | |
| SCHEMBL909696 | 0.77 | CA1 (0.38) | CYP24A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016009296-A1 | N-ACYLPIPERIDINE ETHER TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER INC. (US) | 2016-01-21 | — | — | WO | disclosed |