Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17440026 | 0.81 | CHRM1 (0.41) | P4HTMKDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL17440142 | 0.80 | CHRM1 (0.44) | KMT2ACHRM1PDE2APDE11A | |
| SCHEMBL17440130 | 0.80 | CHRM1 (0.61) | P4HTMKDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL17440123 | 0.79 | CHRM1 (0.65) | CHRM1 | |
| SCHEMBL17440138 | 0.79 | CHRM1 (0.44) | LMNAMAPTTDP1CHRM1PDE2A | |
| SCHEMBL17440089 | 0.79 | AXL (0.40) | KDM4EALDH1A1L3MBTL1CHRM1PDE2A | |
| SCHEMBL18725363 | 0.74 | GABRP (0.46) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL12810913 | 0.74 | KDM4E (0.49) | P4HTMKDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL27671512 | 0.74 | RXRA (0.51) | MEN1ALDH1A1LMNATSHRKMT2A | |
| SCHEMBL18725435 | 0.73 | ALDH1A1 (0.47) | KDM4EALDH1A1CYP1A2CYP3A4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016009297-A1 | PYRIDINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | PFIZER INC. (US) | 2016-01-21 | — | — | WO | disclosed |