Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17448003 | 0.74 | P4HTM (0.45) | RXRASRD5A2TSHRMEN1LMNA | |
| SCHEMBL27986872 | 0.72 | TSHR (0.69) | RXRASRD5A2TSHRRXRBRXRG | |
| SCHEMBL11143781 | 0.71 | SRD5A2 (0.60) | RXRASRD5A2TSHRRXRBRXRG | |
| SCHEMBL4052411 | 0.71 | MEN1 (0.55) | RXRASRD5A2TSHRRXRBRXRG | |
| SCHEMBL11967061 | 0.70 | NOS3 (0.44) | FFAR1KMT2AALDH1A1 | |
| SCHEMBL27561164 | 0.70 | ALDH1A1 (0.59) | RXRASRD5A2TSHRRXRBKMT2A | |
| SCHEMBL6493687 | 0.69 | TSHR (0.56) | RXRASRD5A2TSHRRXRBRXRG | |
| SCHEMBL19641022 | 0.69 | SHBG (0.38) | FFAR1MEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL22104750 | 0.69 | RXRA (0.51) | RXRASRD5A2TSHRRXRBRXRG | |
| SCHEMBL28776652 | 0.68 | KMT2A (0.58) | RXRASRD5A2TSHRRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1863780-A | Protein kinase inhibitor and application thereof | VERTEX PHARMA (US) | 2006-11-15 | — | — | CN | disclosed |