Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | CNR2 | P34972 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793162 | 0.88 | NPSR1 (0.50) | NPSR1CNR1CNR2HTTSLC6A9 | |
| SCHEMBL377735 | 0.82 | KMT2A (0.51) | NPSR1CNR1CNR2HTTSLC6A9 | |
| SCHEMBL1094296 | 0.80 | KMT2A (0.44) | NPSR1CNR1CNR2HTTSLC6A9 | |
| SCHEMBL27717381 | 0.80 | SLC6A9 (0.48) | NPSR1CNR1CNR2HTTSLC6A9 | |
| SCHEMBL13889298 | 0.80 | SLC6A9 (0.51) | NPSR1CNR1CNR2HTTSLC6A9 | |
| SCHEMBL21640928 | 0.78 | SLC6A9 (0.50) | NPSR1CNR1CNR2HTTSLC6A9 | |
| SCHEMBL27717458 | 0.78 | CACNA1A (0.49) | NPSR1CNR1CNR2HTTSLC6A9 | |
| SCHEMBL18614912 | 0.77 | CNR1 (0.56) | NPSR1CNR1CNR2HTTSLC6A9 | |
| SCHEMBL15669852 | 0.76 | SMN1; SMN2 (0.47) | CNR1CNR2HTTSLC6A9ALDH1A1 | |
| SCHEMBL1104991 | 0.75 | OPRM1 (0.44) | NPSR1CNR1CNR2HTTSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2914586-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | Pfizer Inc. (US) | 2015-09-09 | — | — | EP | disclosed |
| WO-2014068527-A1 | BRUTON'S TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 2014-05-08 | — | — | WO | disclosed |
| EP-2385938-A1 | SULFONAMIDE DERIVATIVES | Pfizer Limited (GB) | 2011-11-16 | — | — | EP | disclosed |
| US-8040476-B2 | Display device and method of producing the same | MITSUBISHI ELECTRIC CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |
| WO-2010079443-A1 | SULFONAMIDE DERIVATIVES | PFIZER LIMITED (GB) | 2010-07-15 | — | — | WO | disclosed |