Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 11/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.34 |
| ▸ | DRD2 | P14416 | 8/20 | 0.34 |
| ▸ | DRD4 | P21917 | 8/20 | 0.34 |
| ▸ | DRD3 | P35462 | 8/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1746770 | 0.79 | CYP11B2 (0.40) | BRD4 | |
| SCHEMBL1744203 | 0.74 | HDAC1 (0.36) | ATAD2CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL3344187 | 0.74 | ATAD2 (0.43) | ATAD2CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL10130299 | 0.74 | GRIN1 (0.46) | ATAD2CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL3344184 | 0.73 | PYGL (0.30) | — | |
| SCHEMBL13386729 | 0.71 | ATAD2 (0.47) | ATAD2CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL3599801 | 0.71 | ATAD2 (0.68) | ATAD2CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL3599798 | 0.71 | ATAD2 (0.46) | ATAD2CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL14277003 | 0.69 | POLB (0.61) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL1744658 | 0.69 | SRD5A1 (0.38) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385939-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-11-16 | — | — | EP | claimed |
| US-8041551-B1 | Algorithm and architecture for multi-argument associative operations that minimizes the number of components using a latency of the components | THE MATHWORKS, INC. (US) | 2011-10-18 | — | — | US | claimed |
| WO-2010072597-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | claimed |
| US-20100160373-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | claimed |
| US-8372865-B2 | Dihydropyridone amides as P2X7 modulators | ROCHE PALO ALTO LLC (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2385939-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-11-16 | — | — | EP | disclosed |
| US-8041551-B1 | Algorithm and architecture for multi-argument associative operations that minimizes the number of components using a latency of the components | THE MATHWORKS, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2010072597-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |
| US-20100160373-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160373-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX3, P2RX1 | ATAD2 2666/4885CHRM1 71/4885CHRM2 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.