Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1464500 | 0.91 | GLS (0.38) | GLSMAPTLMNACYP3A4ALDH1A1 | |
| SCHEMBL1746128 | 0.85 | GLS (0.34) | GLSCYP3A4ALDH1A1 | |
| SCHEMBL31716743 | 0.76 | GLS (0.42) | GLSMAPTLMNACYP3A4MAOB | |
| SCHEMBL1024276 | 0.74 | NOS1 (0.53) | MAPTNOS1LMNACYP3A4ALOX15 | |
| SCHEMBL16931512 | 0.73 | GLS (0.61) | GLSMAPTLMNAMAOBALDH1A1 | |
| SCHEMBL1746766 | 0.72 | HTR2A (0.32) | — | |
| SCHEMBL1463344 | 0.72 | HTR2A (0.32) | — | |
| SCHEMBL1744241 | 0.72 | DUT (0.40) | MAPTLMNAALDH1A1 | |
| SCHEMBL16899218 | 0.71 | KMT2A (0.35) | MAPTLMNACYP3A4POLBALDH1A1 | |
| SCHEMBL1026662 | 0.70 | NOS1 (0.54) | MAPTNOS1LMNACYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385939-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-11-16 | — | — | EP | disclosed |
| US-8041551-B1 | Algorithm and architecture for multi-argument associative operations that minimizes the number of components using a latency of the components | THE MATHWORKS, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2010072597-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |