SCHEMBL1746215

SCHEMBL1746215

O=C(O)C(Cc1ccccc1)n1c(=O)c2sc3c(=O)n(C(Cc4ccccc4)C(=O)O)c(=O)c3sc2c1=O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.59
L3MBTL1 Q9Y468 3/20 0.59
POLB P06746 3/20 0.59
HSD17B10 Q99714 2/20 0.59
KMT2A Q03164 2/20 0.59
KDM4E B2RXH2 1/20 0.59
MEN1 O00255 1/20 0.59
CYP2C9 P11712 1/20 0.59
CYP2C19 P33261 1/20 0.59
PTPN7 P35236 1/20 0.59
RECQL P46063 1/20 0.59
BLM P54132 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
NPSR1 Q6W5P4 1/20 0.54
ALDH1A1 P00352 4/20 0.54
PKM P14618 2/20 0.54
GAA P10253 1/20 0.54
AADAT Q8N5Z0 1/20 0.49
LMNA P02545 1/20 0.48
ALOX15 P16050 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5791501 0.88 POLB (0.69) MAPTL3MBTL1POLBHSD17B10KMT2A
SCHEMBL2454105 0.88 POLB (0.69) MAPTL3MBTL1POLBHSD17B10KMT2A
SCHEMBL2115617 0.75 MAPT (1.00) MAPTL3MBTL1POLBHSD17B10KMT2A
SCHEMBL9554515 0.75 MAPT (1.00) MAPTL3MBTL1POLBHSD17B10KMT2A
SCHEMBL6518219 0.75 POLB (0.60) MAPTL3MBTL1POLBHSD17B10KMT2A
SCHEMBL15387048 0.74 HSD17B10 (0.62) MAPTL3MBTL1POLBHSD17B10KMT2A
SCHEMBL9556012 0.73 POLB (0.50) MAPTL3MBTL1POLBHSD17B10KMT2A
SCHEMBL7269730 0.73 HSD17B10 (0.61) MAPTL3MBTL1POLBHSD17B10KMT2A
SCHEMBL6313528 0.72 POLB (0.60) MAPTL3MBTL1POLBHSD17B10KMT2A
SCHEMBL2868807 0.71 HSD17B10 (0.47) MAPTL3MBTL1POLBHSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2386203-B1 Use of dithiin tetracarboximides for combating phytopathogenic fungi BAYER CROPSCIENCE AG (DE) 2013-11-20 EP claimed
EP-2386203-A2 Use of dithiin tetracarboximides for combating phytopathogenic fungi Bayer CropScience AG (DE) 2011-11-16 EP claimed
US-8040455-B2 Display device and information processing device having the same SAMSUNG ELECTRONICS CO., LTD. (KR) 2011-10-18 US claimed
US-9095140-B2 Use of dithiine-tetracarboximides for controlling phytopathogenic fungi BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-08-04 US disclosed
US-20150065551-A1 Use of Dithiine-tetracarboximides for Controlling Phytopathogenic Fungi BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-05 US disclosed
US-8865759-B2 Use of dithiine-tetracarboximides for controlling phytopathogenic fungi BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-10-21 US disclosed
EP-2386203-B1 Use of dithiin tetracarboximides for combating phytopathogenic fungi BAYER CROPSCIENCE AG (DE) 2013-11-20 EP disclosed
US-20110319462-A1 Use of Dithiine-tetracarboximides for Controlling Phytopathogenic Fungi BAYER CROPSCIENCE AG 2011-12-29 US disclosed
EP-2386203-A2 Use of dithiin tetracarboximides for combating phytopathogenic fungi Bayer CropScience AG (DE) 2011-11-16 EP disclosed
US-8040455-B2 Display device and information processing device having the same SAMSUNG ELECTRONICS CO., LTD. (KR) 2011-10-18 US disclosed
US-20100120884-A1 USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING PHYTOPATHOGENIC FUNGI BAYER CROPSCIENCE AG (DE) 2010-05-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100120884-A1 USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING PHYTOPATHOGENIC FUNGI TST, TTI1, DPM1 MAPT 1039/4885L3MBTL1 1451/4885POLB 4367/4885
US-20110319462-A1 Use of Dithiine-tetracarboximides for Controlling Phytopathogenic Fungi TST, TTI1, DPM1 MAPT 1039/4885L3MBTL1 1451/4885POLB 4367/4885
US-20150065551-A1 Use of Dithiine-tetracarboximides for Controlling Phytopathogenic Fungi TST, TTI1, DPM1 MAPT 1039/4885L3MBTL1 1451/4885POLB 4367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.