Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27847428 | 0.77 | GPR84 (0.40) | CTNNB1WNT3AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL1353154 | 0.77 | CYP1A2 (0.51) | CTNNB1WNT3AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL12606659 | 0.75 | CTNNB1 (0.42) | CTNNB1WNT3AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL29464955 | 0.75 | ALDH1A1 (0.46) | CTNNB1WNT3AKDM4EHSD17B10MEN1 | |
| SCHEMBL12606661 | 0.75 | PBRM1 (0.46) | CTNNB1WNT3AKDM4EHSD17B10MEN1 | |
| SCHEMBL11793589 | 0.71 | CTNNB1 (0.49) | CTNNB1WNT3AKDM4EMEN1KMT2A | |
| SCHEMBL11793596 | 0.71 | CTNNB1 (0.49) | CTNNB1WNT3AKDM4EHSD17B10MEN1 | |
| SCHEMBL1350659 | 0.70 | KDM4E (0.67) | CTNNB1WNT3AKDM4EHSD17B10MEN1 | |
| SCHEMBL27387168 | 0.69 | GPR84 (0.44) | CTNNB1WNT3AKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL3676142 | 0.69 | CYP2A6 (0.58) | CTNNB1WNT3AAXLKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160022665-A2 | Pharmaceutical Compositions and Administrations Thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2016-01-28 | — | — | US | disclosed |
| US-20160022665-A2 | Pharmaceutical Compositions and Administrations Thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022665-A2 | Pharmaceutical Compositions and Administrations Thereof | CFTR, ABCB11, SLC26A4 | CTNNB1 3628/4885WNT3A 2465/4885KDM4E 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.