Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17464696 | 0.83 | FAAH (0.36) | PDE10APDE2APDE5A | |
| SCHEMBL17464703 | 0.80 | PTGS2 (0.39) | PTGS2BCHEACHERAB9A | |
| SCHEMBL19914142 | 0.78 | PTGS2 (0.33) | PTGS2BCHEACHE | |
| SCHEMBL27688938 | 0.75 | PTGS2 (0.53) | PTGS2PPARACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24327752 | 0.75 | FFAR1 (0.47) | PTGS2PPARALMNABCHEACHE | |
| SCHEMBL17464694 | 0.74 | PDE10A (0.59) | PTGS2PDE10APDE2APDE5A | |
| SCHEMBL17464699 | 0.74 | PDE10A (0.59) | PTGS2PDE10APDE2APDE5A | |
| SCHEMBL17464693 | 0.74 | PDE10A (0.59) | PTGS2PDE10APDE2APDE5A | |
| SCHEMBL2388630 | 0.72 | TP53 (0.44) | PDE10APDE2APDE5ARAB9A | |
| SCHEMBL10355170 | 0.72 | ESR1 (0.44) | PTGS2PPARACYP1A2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180057484-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | OMEROS CORP (US) | 2018-03-01 | — | — | US | disclosed |
| US-9850238-B2 | Optically active PDE10 inhibitor | OMEROS CORPORATION (US) | 2017-12-26 | — | — | US | disclosed |
| US-9650368-B2 | Processes and intermediates for the preparation of a PDE10 inhibitor | OMEROS CORPORATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-20170096420-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | OMEROS CORPORATION | 2017-04-06 | — | — | US | disclosed |
| US-9493447-B2 | Optically active PDE10 inhibitor | OMEROS CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160024070-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | OMEROS CORPORATION | 2016-01-28 | — | — | US | disclosed |
| US-20160024069-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | OMEROS CORPORATION | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170096420-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | PDE3A, PDE10A, PDE3B | PTGS2 661/4885PDE10A 2/4885PDE2A 5/4885 |
| US-20180057484-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | PDE3A, PDE3B, PDE5A | PTGS2 284/4885PDE10A 5/4885PDE2A 4/4885 |
| US-20160024069-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | PDE3A, PDE3B, PDE5A | PTGS2 284/4885PDE10A 5/4885PDE2A 4/4885 |
| US-20160024070-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | PDE3A, PDE10A, PDE3B | PTGS2 731/4885PDE10A 2/4885PDE2A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.