Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.39 |
| ▸ | ACHE | P22303 | 7/20 | 0.39 |
| ▸ | BCHE | P06276 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19914142 | 0.91 | PTGS2 (0.33) | PTGS2ACHEBCHE | |
| SCHEMBL17464702 | 0.80 | PTGS2 (0.34) | PTGS2ACHEBCHERAB9A | |
| SCHEMBL17464696 | 0.75 | FAAH (0.36) | — | |
| SCHEMBL6394314 | 0.73 | PTGS2 (0.57) | PTGS2ACHEBCHENPC1RAB9A | |
| SCHEMBL27432182 | 0.73 | NISCH (0.40) | NPC1RAB9A | |
| SCHEMBL14016423 | 0.72 | NPC1 (0.41) | ACHENPC1RAB9A | |
| SCHEMBL3906858 | 0.69 | ACHE (0.50) | PTGS2ACHEBCHENPC1RAB9A | |
| SCHEMBL22311218 | 0.69 | PTGS2 (0.46) | PTGS2ACHEBCHE | |
| SCHEMBL12427251 | 0.68 | DDX3X (0.41) | NPC1RAB9A | |
| SCHEMBL15442019 | 0.67 | ACHE (0.49) | PTGS2ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180057484-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | OMEROS CORP (US) | 2018-03-01 | — | — | US | disclosed |
| US-9850238-B2 | Optically active PDE10 inhibitor | OMEROS CORPORATION (US) | 2017-12-26 | — | — | US | disclosed |
| US-9650368-B2 | Processes and intermediates for the preparation of a PDE10 inhibitor | OMEROS CORPORATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-20170096420-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | OMEROS CORPORATION | 2017-04-06 | — | — | US | disclosed |
| US-9493447-B2 | Optically active PDE10 inhibitor | OMEROS CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160024070-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | OMEROS CORPORATION | 2016-01-28 | — | — | US | disclosed |
| US-20160024069-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | OMEROS CORPORATION | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170096420-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | PDE3A, PDE10A, PDE3B | PTGS2 661/4885ACHE 350/4885BCHE 3677/4885 |
| US-20180057484-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | PDE3A, PDE3B, PDE5A | PTGS2 284/4885ACHE 87/4885BCHE 1672/4885 |
| US-20160024069-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | PDE3A, PDE3B, PDE5A | PTGS2 284/4885ACHE 87/4885BCHE 1672/4885 |
| US-20160024070-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | PDE3A, PDE10A, PDE3B | PTGS2 731/4885ACHE 360/4885BCHE 3708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.