Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 3/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17024 | 0.88 | NR1D1 (0.36) | NR1D1CXCR4TDO2KMT2AALDH1A1 | |
| SCHEMBL17464 | 0.85 | NR1D1 (0.38) | NR1D1CXCR4TDO2KMT2AALDH1A1 | |
| SCHEMBL18134 | 0.74 | ALDH1A1 (0.30) | ALDH1A1LMNAMAPT | |
| SCHEMBL16510 | 0.73 | GCKR (0.38) | NR1D1TDO2KMT2AALDH1A1LMNA | |
| SCHEMBL17115 | 0.73 | NR1D1 (0.31) | NR1D1TDO2 | |
| SCHEMBL17564 | 0.72 | GCKR (0.41) | — | |
| SCHEMBL18132 | 0.71 | ALDH1A1 (0.31) | NR1D1KMT2AALDH1A1MAPT | |
| SCHEMBL18384 | 0.71 | NR1D1 (0.31) | NR1D1TDO2 | |
| SCHEMBL17165 | 0.71 | NR1D1 (0.31) | NR1D1TDO2 | |
| SCHEMBL12089538 | 0.71 | NR1D1 (0.31) | NR1D1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |