Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18132 | 0.85 | ALDH1A1 (0.31) | ALDH1A1MAPT | |
| SCHEMBL18123 | 0.81 | PKM (0.39) | ALDH1A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL17115 | 0.78 | NR1D1 (0.31) | — | |
| SCHEMBL16510 | 0.77 | GCKR (0.38) | ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL17382 | 0.76 | GCKR (0.38) | — | |
| SCHEMBL17466 | 0.74 | NR1D1 (0.37) | ALDH1A1LMNAMAPT | |
| SCHEMBL17165 | 0.73 | NR1D1 (0.31) | — | |
| SCHEMBL18384 | 0.73 | NR1D1 (0.31) | — | |
| SCHEMBL12089538 | 0.73 | NR1D1 (0.31) | — | |
| SCHEMBL17464 | 0.72 | NR1D1 (0.38) | ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |