SCHEMBL1746642

SCHEMBL1746642

COC(=O)CCc1ccc(OCc2ccc(-c3c(C)cccc3C)s2)cc1

nearest known ligand 0.48

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 14/20 0.48
VDR P11473 2/20 0.47
PPARD Q03181 1/20 0.47
RPS6KB2 Q9UBS0 1/20 0.45
FFAR4 Q5NUL3 2/20 0.42
ADRB2 P07550 1/20 0.42
ADRB1 P08588 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1744980 0.89 FFAR1 (0.61) FFAR1PPARDFFAR4
SCHEMBL1746718 0.80 FFAR1 (0.62) FFAR1VDRPPARDFFAR4
SCHEMBL1744706 0.79 ADRB2 (0.47) FFAR1VDRPPARDFFAR4ADRB2
SCHEMBL1747205 0.77 FFAR1 (0.79) FFAR1FFAR4
SCHEMBL1745358 0.76 FFAR1 (0.79) FFAR1VDRPPARDFFAR4
SCHEMBL28388911 0.76 FFAR1 (0.80) FFAR1VDRPPARDRPS6KB2FFAR4
SCHEMBL1744704 0.75 FFAR1 (0.51) FFAR1VDRPPARDFFAR4ADRB2
SCHEMBL1744946 0.75 FFAR1 (0.56) FFAR1VDRPPARDFFAR4
SCHEMBL1747394 0.75 FFAR1 (0.82) FFAR1VDRPPARDFFAR4
SCHEMBL12646512 0.74 FFAR1 (0.54) FFAR1VDRPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885VDR 117/4885PPARD 326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.