SCHEMBL1744706

SCHEMBL1744706

COC(=O)CCc1ccc(OCc2ccc(Br)s2)cc1

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.47
ADRB1 P08588 1/20 0.47
FFAR1 O14842 11/20 0.46
FFAR4 Q5NUL3 4/20 0.46
VDR P11473 2/20 0.45
PPARD Q03181 1/20 0.44
F2RL1 P55085 1/20 0.41
PPARG P37231 1/20 0.41
IDO1 P14902 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5320621 0.80 RPS6KB2 (0.51) PPARGIDO1
SCHEMBL2828491 0.80 FFAR1 (0.71) ADRB2ADRB1FFAR1FFAR4IDO1
SCHEMBL1746642 0.79 FFAR1 (0.48) ADRB2ADRB1FFAR1FFAR4VDR
SCHEMBL1745363 0.77 FFAR1 (0.58) ADRB2ADRB1FFAR1FFAR4VDR
SCHEMBL28549048 0.76 ADRB2 (0.54) ADRB2ADRB1FFAR1F2RL1PPARG
SCHEMBL1747331 0.76 VDR (0.49) ADRB2ADRB1FFAR1FFAR4VDR
SCHEMBL15679198 0.75 FFAR1 (0.60) ADRB2ADRB1FFAR1FFAR4VDR
SCHEMBL1745247 0.75 FFAR1 (0.72) FFAR1FFAR4
SCHEMBL1747136 0.75 FFAR1 (0.72) FFAR1FFAR4
SCHEMBL7474007 0.75 HPGD (0.58)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR ADRB2 316/4885ADRB1 137/4885FFAR1 33/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.