SCHEMBL17467929

SCHEMBL17467929

O=Cc1ccc(Oc2ccc(F)c(C(F)(F)F)c2)nc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.63
L3MBTL1 Q9Y468 2/20 0.63
POLB P06746 2/20 0.63
KDM4E B2RXH2 3/20 0.55
KIF11 P52732 1/20 0.40
THRB P10828 1/20 0.40
MAPK1 P28482 1/20 0.40
KCNH2 Q12809 2/20 0.39
HTR2A P28223 1/20 0.39
SLC6A4 P31645 1/20 0.39
CASP6 P55212 1/20 0.39
CDK8 P49336 2/20 0.38
RXRA P19793 2/20 0.37
GRIN1 Q05586 2/20 0.37
GRIN2B Q13224 2/20 0.37
PLA2G7 Q13093 1/20 0.37
MAPT P10636 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
KDR P35968 1/20 0.37
SLC22A12 Q96S37 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL875480 0.86 ALDH1A1 (0.62) ALDH1A1L3MBTL1POLBKDM4ETHRB
SCHEMBL1283899 0.82 KIF11 (0.51) ALDH1A1L3MBTL1POLBKDM4EKIF11
SCHEMBL875765 0.82 ALDH1A1 (0.41) ALDH1A1L3MBTL1POLBKDM4EKIF11
SCHEMBL16838774 0.81 KDM4E (0.65) ALDH1A1L3MBTL1POLBKDM4EMAPK1
SCHEMBL16762118 0.79 ALDH1A1 (0.71) ALDH1A1L3MBTL1POLBKDM4ETHRB
SCHEMBL17459901 0.79 KIF11 (0.40) ALDH1A1L3MBTL1POLBKIF11THRB
SCHEMBL29918246 0.79 KIF11 (0.40) ALDH1A1L3MBTL1POLBKIF11THRB
SCHEMBL16838773 0.78 ALDH1A1 (0.65) ALDH1A1L3MBTL1POLBKDM4EMAPK1
SCHEMBL876853 0.77 L3MBTL1 (1.00) ALDH1A1L3MBTL1POLBKDM4ETHRB
SCHEMBL24998714 0.77 THRB (0.50) L3MBTL1POLBKDM4ETHRBMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240300965-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2024-09-12 US disclosed
US-11999746-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2024-06-04 US disclosed
US-20200055863-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2020-02-20 US disclosed
US-20200055863-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2020-02-20 US disclosed
US-10428078-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-10-01 US disclosed
US-10428078-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-10-01 US disclosed
EP-3172211-B1 TRICYCLIC IMIDAZO-PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY LP-PLA2 GLAXOSMITHKLINE IP DEV LTD (GB) 2019-07-03 EP disclosed
EP-3172211-B1 TRICYCLIC IMIDAZO-PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY LP-PLA2 GLAXOSMITHKLINE IP DEV LTD (GB) 2019-07-03 EP disclosed
US-20190023715-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-01-24 US disclosed
US-20190023715-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-01-24 US disclosed
US-10125141-B2 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2018-11-13 US disclosed
US-20170204109-A1 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-07-20 US disclosed
US-20170204109-A1 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-07-20 US disclosed
US-20170204109-A1 Compounds GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-07-20 US disclosed
WO-2016011930-A1 COMPOUNDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2016-01-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200055863-A1 COMPOUNDS PLAAT2, PLA2G12A, PLA2G1B ALDH1A1 2222/4885L3MBTL1 3347/4885POLB 3233/4885
US-20190023715-A1 COMPOUNDS PLAAT2, PLA2G12A, PLA2G1B ALDH1A1 2222/4885L3MBTL1 3347/4885POLB 3233/4885
US-10125141-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B ALDH1A1 2222/4885L3MBTL1 3347/4885POLB 3233/4885
US-10428078-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B ALDH1A1 2222/4885L3MBTL1 3347/4885POLB 3233/4885
US-20240300965-A1 COMPOUNDS PLAAT2, PLA2G12A, PLA2G1B ALDH1A1 2222/4885L3MBTL1 3347/4885POLB 3233/4885
US-11999746-B2 Compounds PLAAT2, PLA2G12A, PLA2G1B ALDH1A1 2222/4885L3MBTL1 3347/4885POLB 3233/4885
US-20170204109-A1 Compounds PLAAT2, PLA2G12A, PLA2G1B ALDH1A1 2222/4885L3MBTL1 3347/4885POLB 3233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.